General synthesis of (1-substituted-1H-1,2,3-triazol-4-ylmethyl)-dialkylamines via a copper(I)-catalyzed three-component reaction in water
General synthesis of (1-substituted-1H-1,2,3-triazol-4-ylmethyl)-dialkylamines via a copper(I)-catalyzed three-component reaction in water
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DOI：
10.1016/j.tet.2005.07.060
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发表时间：
2005-09-26
期刊：
影响因子：
2.1
通讯作者：
Liang, YM
中科院分区：
文献类型：
--
作者：
Yan, ZY;Zhao, YB;Liang, YM
提出了一种铜（I）催化的三组分反应合成（1 -取代-1H-1，2，3-三唑-4-基甲基）-二烷基胺的方法，该反应基于胺、炔丙基卤和叠氮在水中的Huisgen环加成反应。该工艺具有原子经济性高、环境影响小、常压氧、底物范围广、反应条件温和、产率高等优点。(c)2005年由Elsevier Ltd.出版
A copper(l)-catalyzed three-component reaction to form (1 -substituted- 1H- 1,2,3-triazol-4-ylmethyl)-dialkylamines based on the Huisgen cycloaddition using amine, propargyl halide and azide in water was proposed. The process showed considerable synthetic advantages in terms of high atom economy, low environmental impact, atmospheric oxygen, wide substrate scope, mild reaction condition and good yields. (c) 2005 Published by Elsevier Ltd.