Effects of low dose endotoxemia on endothelial progenitor cells in humans.
Effects of low dose endotoxemia on endothelial progenitor cells in humans.
复制标题
DOI：
10.1016/j.atherosclerosis.2007.04.003
复制
发表时间：
2007-11-01
期刊：
影响因子：
5.3
通讯作者：
Jilma, B
中科院分区：
文献类型：
--
作者：
Mayr, F B;Spiel, A O;Jilma, B
背景：内皮祖细胞（EPC）是造血干细胞的一种特殊亚型，它们从骨髓迁移到外周循环，在那里它们有助于修复受损的内皮并形成新血管。已对不同炎症性疾病状态下的循环 EPC 水平进行了研究。然而，关于循环 EPC 水平和全身炎症的数据仍然稀缺且相互矛盾。 目的：我们研究了低度实验性内毒素血症与循环 EPC 水平变化的假定关系。 方法：在 36 名健康男性志愿者中进行随机、双盲、安慰剂对照平行组试验。 32 名志愿者静脉注射 2 ng/kg LPS，其余 4 名志愿者接受等体积的生理盐水溶液作为安慰剂。 结果：在观察期间，接受 LPS 攻击的 32 名受试者中，内皮祖细胞显示出显着减少（P
BACKGROUND: Endothelial progenitor cells (EPCs) are a specific subtype of hematopoietic stem cells that migrate from the bone marrow to the peripheral circulation where they contribute to the repair of injured endothelium and to the formation of new blood vessels. Levels of circulating EPCs have been investigated in different inflammatory disease states. However, data on circulating EPC levels and systemic inflammation remain scarce and contradictory.OBJECTIVE: We investigated a putative relationship of low grade experimental endotoxemia to changes in circulating EPC levels.METHODS: Randomized, double-blind, placebo-controlled parallel group trial in 36 healthy male volunteers. Thirty-two volunteers received 2 ng/kg LPS intravenously, the remaining four an equal volume of physiologic saline solution as placebo.RESULTS: Endothelial progenitor cells showed a significant decrease over the observation period among the 32 subjects challenged with LPS (P