Dopamine D2 receptor occupancy in vivo by the novel atypical antipsychotic olanzapine — a123 IBZM single photon emission tomography (SPET) study
Dopamine D2 receptor occupancy in vivo by the novel atypical antipsychotic olanzapine — a123 IBZM single photon emission tomography (SPET) study
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新型非典型抗精神病药物奥氮平体内多巴胺 D2 受体的占用 — a123 IBZM 单光子发射断层扫描 (SPET) 研究
DOI：
10.1007/bf02245615
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发表时间：
1996
影响因子：
3.4
通讯作者：
V. Nohria
中科院分区：
文献类型：
--
作者：
L. Pilowsky;G. Busatto;M. Taylor;T. Sharma;T. Sigmundsson;D. Costa;P. Ell;V. Nohria
我们研究了纹状体D2多巴胺结合治疗的新型非典型抗精神病药物，奥氮平精神分裂症患者。123碘苯甲酰胺（IBZM）单光子发射断层扫描（SPET）被用来估计纹状体多巴胺D2受体结合在体内。从奥氮平与氟哌啶醇治疗的前瞻性、双盲对照试验中招募患者。将奥氮平治疗患者（n=6）的体内纹状体D2结合数据与先前报道的典型抗精神病药应答（n=10）、氯氮平（n=10）和利培酮（n=6）治疗患者组的数据进行比较。奥氮平治疗后简明精神病评定量表评分（BPRS）平均改善%为49%（SD 44）。奥氮平治疗患者的临床改善与123I IBZM的平均纹状体D2结合率（反映较低水平的D2占用率）高于典型抗精神病药（1.25±0.05）或利培酮（1.24±0.04）治疗相关的假设得到证实。奥氮平治疗患者体内纹状体D2结合水平（1.41±0.06）与氯氮平治疗患者相似（1.49±0.04）。这一初步证据表明，奥氮平是另一种非典型抗精神病药物，其治疗反应与体内纹状体D2受体的高度占有无关。
We have studied striatal D2 dopamine binding in schizophrenic patients treated with the novel atypical antipsychotic drug, olanzapine.123I iodobenzamide (IBZM) single photon emission tomography (SPET) was used to estimate striatal dopamine D2 receptor binding in vivo. Patients were recruited from a prospective, double blind controlled trial of olanzapine versus haloperidol treatment. In vivo striatal D2 binding data from olanzapine treated patients (n=6) were compared with previously reported data from typical antipsychotic responsive (n=10); clozapine (n=10); and risperidone (n=6) treated patient groups. Mean % Brief Psychiatric Rating Scale score (BPRS) improvement following olanzapine treatment was 49% (SD 44). The hypothesis that clinical improvement in olanzapine treated patients would be associated with higher mean striatal D2 binding of123I IBZM (reflecting lower levels of D2 occupancy) than typical antipsychotic (1.25±0.05) or risperidone (1.24±0.04) treatment was confirmed. Olanzapine treated patients had similar levels of striatal D2 binding in vivo (1.41±0.06) as those treated with clozapine (1.49±0.04). This preliminary evidence suggests olanzapine is another atypical antipsychotic drug in which therapeutic response is not associated with a high degree of striatal D2 receptor occupancy in vivo.
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影响因子：
--
作者：
L. Farde;A. Nordström;F. Wiesel;S. Pauli;C. Halldin;G. Sedvall
通讯作者：
L. Farde;A. Nordström;F. Wiesel;S. Pauli;C. Halldin;G. Sedvall
纹状体外多巴胺 D2 受体：氯氮平的分布、药理学特征和区域特异性调节。
DOI：
--
发表时间：
1992
期刊：
The Journal of pharmacology and experimental therapeutics
影响因子：
--
作者：
Janowsky,A;Neve,KA;Kinzie,JM;Taylor,B;dePaulis,T;Belknap,JK
通讯作者：
Belknap,JK
使用 iodine-123-IBZM 对人体多巴胺 D2 受体进行动态 SPECT 成像。
DOI：
--
发表时间：
1992
期刊：
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
影响因子：
--
作者：
Seibyl,JP;Woods,SW;Zoghbi,SS;Baldwin,RM;Dey,HM;Goddard,AW;Zea-Ponce,Y;Zubal,G;Germine,M;Smith,EO
通讯作者：
Smith,EO
DOI：
10.1073/pnas.91.10.4353
发表时间：
1994-05-10
影响因子：
11.1
作者：
LIDOW, MS;GOLDMANRAKIC, PS
通讯作者：
GOLDMANRAKIC, PS