Association of glutathione peroxidase activity with insulin resistance and dietary fat intake during normal pregnancy
Association of glutathione peroxidase activity with insulin resistance and dietary fat intake during normal pregnancy
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DOI：
10.1210/jc.2003-030544
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发表时间：
2003-12-01
影响因子：
5.8
通讯作者：
Stein, TP
中科院分区：
文献类型：
--
作者：
Chen, XH;Scholl, TO;Stein, TP
谷胱甘肽过氧化物酶（GPx）是人类最重要的抗氧化酶之一。我们研究了来自新泽西州卡姆登的 408 名血压正常的非糖尿病孕妇的红细胞 GPx 活性与空腹血清胰岛素、血浆葡萄糖和 C 肽之间的关系，根据稳态评估模型估计的胰岛素抵抗以及膳食脂肪摄入量。 GPx 活性和代谢参数在开始护理时（怀孕 16 周）和妊娠晚期进行测定。 GPx 活性和胰岛素抵抗水平在进入和妊娠晚期之间显着增加。 GPx 活性与空腹胰岛素（β = 0.009，P < 0.001）、葡萄糖（β = 0.975，P < 0.05）、C 肽（β = 1.537，P < 0.01）和稳态评估模型的胰岛素抵抗（（β = 0.209，P < 0.01）之间观察到统计学上显着的相关性，均为阳性。 0.01）。非洲裔美国人的 GPx 活性、膳食脂肪和多不饱和脂肪酸摄入量显着高于西班牙裔和白种人。总之，我们证明正常妊娠与 GPx 活性和胰岛素抵抗有关。我们的研究结果表明，抗氧化防御、胰岛素抵抗和膳食脂肪摄入之间存在潜在联系。
Glutathione peroxidase (GPx) is one of the most important antioxidant enzymes in humans. We studied the relationship between erythrocyte GPx activity and fasting serum insulin, plasma glucose, and C-peptide, estimates of insulin resistance from the homeostasis model of assessment as well as dietary fat intake in 408 normotensive nondiabetic pregnant women from Camden, NJ. GPx activity and the metabolic parameters were determined at entry to care ( 16 wk of pregnancy) and during the third trimester. GPx activity and the levels of insulin resistance increased significantly between entry and the third trimester. Statistically significant associations, all positive, were observed between GPx activity and fasting insulin (beta = 0.009, P < 0.001), glucose (beta = 0.975, P < 0.05), C-peptide (beta = 1.537, P< 0.01), and insulin resistance from the homeostasis model of assessment ( (beta = 0.209, P < 0.01). Dietary intakes of fat and polyunsaturated fatty acids were positively correlated with GPx activity as well. African Americans had significantly higher GPx activity, dietary fat, and polyunsaturated fatty acid intake than Hispanics and Caucasians. In conclusion, we demonstrated that normal pregnancy is associated with increased GPx activity and insulin resistance. There are ethnic differences in antioxidant response and dietary fat intake. Our findings suggest a potential link among antioxidant defenses, insulin resistance, and dietary fat intake.