Synthesis and Cytotoxic Activities of New Fatty Acid Esters of 20(S)-Protopanaxadiol
Synthesis and Cytotoxic Activities of New Fatty Acid Esters of 20(S)-Protopanaxadiol
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DOI：
10.5560/znc.2011.66c0199
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发表时间：
2011-05-01
影响因子：
2
通讯作者：
Li, Pingya
中科院分区：
文献类型：
--
作者：
Li, Ning;Huang, Yuan;Li, Pingya
为了寻找新的具有抗肿瘤活性的先导化合物，以N，N ′-二环己基碳二亚胺（DCC）和油酰氯或脂肪酸为原料，合成了13个新的20（S）-原人参二醇脂肪酸酯（PPD）。采用MTT法测定了它们的细胞毒活性，并讨论了PPD脂肪酸酯与细胞毒活性的构效关系。
In order to find new lead compounds with antitumour activies, thirteen new fatty acid esters of 20(S)-protopanaxadiol (PPD) were synthesized using oleoyl chloride or fatty acids and N,N'-dicyclohexylcarbodiimide (DCC). Their cytotoxic activities were tested using the MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] method, and the structure-activity relationships between the fatty acid esters of PPD and their cytotoxic activities are discussed.