Chronic life stress alters sympathetic, neuroendocrine, and immune responsivity to an acute psychological stressor in humans
Chronic life stress alters sympathetic, neuroendocrine, and immune responsivity to an acute psychological stressor in humans
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DOI：
10.1097/00006842-199707000-00015
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发表时间：
1997-07-01
影响因子：
3.3
通讯作者：
Irwin, MR
中科院分区：
文献类型：
--
作者：
Pike, JL;Smith, TL;Irwin, MR
目的：生活压力可能改变自主神经、神经内分泌和免疫系统的动态调节。方法：采用受试者内部混合设计，有慢性生活压力（N = 12）和没有慢性生活压力（N = 11）的男性志愿者分别接受12分钟的实验室压力（心算）和视频控制。结果：与视频控制条件相比，急性心理应激引起主观痛苦，肾上腺素、去甲肾上腺素、β -内啡肽、促肾上腺皮质激素（ACTH）和皮质醇循环浓度增加，自然杀伤细胞（NK）选择性重新分布到外周血中。尽管两组在心理、交感、神经内分泌和免疫领域的基线几乎相同，但慢性应激组表现出更大的主观痛苦，肾上腺素峰值水平更高，β -内啡肽和NK细胞溶解峰值水平更低，NK细胞在急性心理挑战下的再分配比对照组更明显。此外，急性应激源诱导慢性应激组每个NK细胞的NK裂解持续下降，但在对照组中没有影响。结论：总之，当慢性生活压力的人面临急性心理挑战时，会出现与个体NK细胞功能下降相关的夸张的心理和高峰交感神经反应，并持续到应激源终止和交感神经恢复之后。
Objective: Life stress is hypothesized to alter the dynamic regulation of the autonomic, neuroendocrine, and immune systems. This study examined the effects of antecedent chronic life stress on psychological and physiological responsivity after acute challenge with a psychological stressor, Method: Using a within-subject mixed design, male volunteers with (N = 12) and without chronic life stress (N = 11) were administered a 12-minute laboratory stressor (mental arithmetic) vs a video control. Results: Acute psychological stress induced subjective distress, increases of circulating concentrations of epinephrine, norepinephrine, beta-endorphin, adrenocorticotropic hormone (ACTH), and cortisol, and a selective redistribution of natural killer (NK) cells into the peripheral blood as compared with the video control condition. Although the two groups were almost identical at baseline in psychological, sympathetic, neuroendocrine, and immune domains, the chronic stress group showed greater subjective distress, higher peak levels of epinephrine, lower peak levels of beta-endorphin and of NK cell lysis, and a more pronounced redistribution of NK cells in response to the acute psychological challenge than the controls. Furthermore, the acute stressor induced a protracted decline in NK lysis per NK cell in the chronic stress group but had no effect in the controls. Conclusions: In summary, when persons who are undergoing chronic life stress are confronted with an acute psychological challenge, an exaggerated psychologic and peak sympathomedullary reactivity occurs that is associated with decrements in individual NK cell function and is protracted beyond termination of the stressor and sympathomedullary recovery.