Vestibular dysfunction in patients with auditory neuropathy detected by vestibular evoked myogenic potentials
Vestibular dysfunction in patients with auditory neuropathy detected by vestibular evoked myogenic potentials
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前庭肌源性诱发电位检测听神经病患者前庭功能障碍
DOI：
10.1016/j.clinph.2020.02.002
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发表时间：
2020-07-01
影响因子：
4.7
通讯作者：
Zhang, Qing
中科院分区：
文献类型：
--
作者：
Hu, Juan;Chen, Zichen;Zhang, Qing
目的：本研究旨在通过眼前庭诱发肌源性电位（oVEMP）、颈前庭诱发肌源性电位（cVEMP）、冷热试验、视频头脉冲试验（vHIT）和抑制头脉冲范式（SHIMP）试验确定听神经病（AN）患者的前庭受累。入选22例AN患者（研究组）和50例年龄和性别匹配的健康受试者（对照组）。所有患者均行气导声oVEMP和cVEMP检测。在研究组中，20例患者进行了冷热试验，10例患者进行了视频头脉冲试验（vHIT），和9例患者进行了抑制头脉冲范式（SHIMP）test.Results：VEMP异常被发现在两组之间的显着差异。大多数AN患者没有VEMP反应，只有少数患者显示VEMP反应，参数正常。部分AN患者出现VEMP参数异常，包括阈值、潜伏期和振幅。cVEMP和oVEMP的异常率分别为91%和86%。oVEMP和cVEMP异常之间无显著差异。AN患者冷热试验异常率为70%。大多数AN患者显示正常VOR增益。大多数患者在vHIT中没有表现出明显的纠正性扫视，在SHIMP test.Conclusion中表现出正常的抗代偿性扫视。许多AN患者经历前庭功能障碍，这可能是通过使用前庭功能测试battery.Significance：VEMP异常可能反映了AN前庭受累的状态和程度。(C)2020国际临床神经生理学联合会。Elsevier B.V.出版，保留所有权利。
Objectives: This study aimed to determine vestibular involvement in patients with auditory neuropathy (AN) using ocular vestibular evoked myogenic potential (oVEMP), cervical vestibular evoked myogenic potential (cVEMP), caloric tests, video Head Impulse Tests (vHIT), and Suppression Head Impulse Paradigm (SHIMP) tests.Methods: Twenty-two patients with AN (study group) and 50 age-and-gender-matched healthy subjects (control group) were enrolled. All patients underwent air-conducted sound oVEMP and cVEMP tests. In the study group, 20 patients underwent a caloric test, 10 patients underwent a video Head Impulse Test (vHIT), and nine patients underwent the Suppression Head Impulse Paradigm (SHIMP) test.Results: Significant differences in VEMP abnormalities were found between the two groups. Most AN patients showed no VEMP response, while only a few patients showed VEMP responses with normal parameters. Some AN patients presented abnormal VEMP parameters, including thresholds, latencies, and amplitudes. The abnormal rate (including no response and abnormal parameters) was 91% in the cVEMP test and 86% in the oVEMP test. No significant difference was found between oVEMP and cVEMP abnormalities. AN patients exhibited a 70% abnormal rate in the caloric test. Most AN patients showed normal VOR gains. Most patients showed no overt corrective saccades in vHIT, and exhibited normal anticompensatory saccades in the SHIMP test.Conclusion: Many AN patients experience vestibular dysfunction, which may be detected by using a vestibular functional test battery.Significance: VEMP abnormalities might reflect the status and degree of vestibular involvement in AN. (C) 2020 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved.