Brain stimulation reveals critical auditory naming cortex
Brain stimulation reveals critical auditory naming cortex
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DOI：
10.1093/brain/awh621
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发表时间：
2005-11-01
期刊：
影响因子：
14.5
通讯作者：
Goodman, RR
中科院分区：
文献类型：
--
作者：
Hamberger, MJ;Seidel, WT;Goodman, RR
显性颞叶癫痫手术的一个挑战是在不影响术后语言功能的情况下切除足够的致癫痫组织。切除前电刺激映射能够识别可以免于切除的语言区域，并且还提供了研究大脑-语言关系的独特机会。视觉物体命名是识别“基本”语言皮层的金标准;然而，保留视觉命名（VN）位点并不能可靠地防止术后语言衰退。除了视觉对象命名，我们还包括一个更“生态有效”的听觉描述命名任务，在我们的切除前皮层映射协议。在7名听觉命名（AN）网站删除的患者中，6名术后下降，而在12名未删除AN网站的患者中，只有3名术后下降（P = 0.02），这表明AN网站删除和术后命名下降之间的关联。有趣的是，虽然VN网站在所有患者中保留，AN网站删除导致听觉和VN任务下降。这些发现不仅具有潜在的重要临床意义，而且还主张模态特异性，在语义系统中具有相当大的整合。
One challenge in dominant temporal lobe epilepsy surgery is to remove sufficient epileptogenic tissue without compromising post-operative language functioning. Pre-resection electrical stimulation mapping enables identification of language areas that can be spared from resection, and also provides a unique opportunity to investigate brain-language relationships. Visual object naming is the gold standard for identifying 'essential' language cortex; however, sparing visual naming (VN) sites has not reliably prevented post-operative language decline. In addition to visual object naming, we included a more 'ecologically valid' auditory description naming task in our pre-resection cortical mapping protocol. Of the seven patients who had auditory naming (AN) sites removed, six declined post-operatively, whereas of the 12 patients who did not have AN sites removed, only 3 declined post-operatively (P = 0.02), suggesting an association between AN site removal and post-operative naming decline. Interestingly, although VN sites were preserved in all patients, AN site removal resulted in decline in both auditory and VN tasks. These findings not only have potentially critical clinical significance, but also argue for modality specificity, with considerable integration within the semantic system.