The Influence of Constrictor Drugs on the Distensibility of the Splanchnic Venous System, Analyzed on the Basis of an Aortic Model
The Influence of Constrictor Drugs on the Distensibility of the Splanchnic Venous System, Analyzed on the Basis of an Aortic Model
复制标题
基于主动脉模型分析收缩药物对内脏静脉系统扩张性的影响
DOI：
10.1161/01.res.2.2.140
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发表时间：
1954
影响因子：
20.1
通讯作者：
R. S. Alexander
中科院分区：
文献类型：
--
作者：
R. S. Alexander
通过以受控速率将血液注射到隔离的节段中来测量麻醉狗的主动脉扩张性。收缩药物在低压范围内使主动脉的扩张性适度增加，在正常压力下使主动脉的扩张性更加显着增加。通过相同的方法以及通过不需要中断血流的方法对肠环的内脏静脉系统的研究提供了与主动脉中所见的相同类型的扩张性现象的证据，尽管在低压下静脉扩张性实际上往往由于血管收缩而降低。内脏静脉系统也与主动脉不同，因为它非常依赖于压力-容积变化的速率。根据所涉及的基本机制及其生理意义对这些结果进行了分析。
The distensibility of the aorta was measured in anesthetized dogs by injecting blood at controlled rates into an isolated segment. Constrictor drugs produce a moderate increase in distensibility of the aorta at low pressure ranges and a more marked increase in distensibility at normal pressures. Studies of the splanchnic venous system of intestinal loops by the same method, and also by a method which does not require interruption in blood flow, gave evidence of the same type of distensibility phenomena as seen in the aorta, although at low pressures the venous distensibility tends to be actually decreased by vasoconstriction. The splanchnic venous system also differs from the aorta in that it is very dependent upon the rate of pressure-volume change. These results are analyzed in terms of the basic mechanisms involved and their physiologic implications.