Acute sexually transmitted infections increase human immunodeficiency virus type 1 plasma viremia, increase plasma type 2 cytokines, and decrease CD4 cell counts
Acute sexually transmitted infections increase human immunodeficiency virus type 1 plasma viremia, increase plasma type 2 cytokines, and decrease CD4 cell counts
复制标题
DOI：
10.1086/315733
复制
发表时间：
2000-08-01
影响因子：
6.4
通讯作者：
Plummer, FA
中科院分区：
文献类型：
--
作者：
Anzala, AO;Simonsen, JN;Plummer, FA
在肯尼亚，血清性工作者中艾滋病潜伏期的中位数为4年；这一潜伏期仅限于女性性工作者。对32例人类免疫缺陷病毒1型(HIV-1)阳性和10例HIV-1阴性的暗娼进行了1~5个月的随访，研究了急性性传播感染(STI)对几项免疫学指标的影响。在STI发作前、中、后测定血浆细胞因子、可溶性细胞因子受体、CD4和CD8T细胞计数以及HIV-1血浆病毒血症。淋球菌性宫颈炎期白介素4、白介素6、白介素10、可溶性肿瘤坏死因子α和病毒血症升高，而CD4(+)T细胞计数下降，治疗后恢复到基线水平。病毒血症的增加与IL-4升高和IL-6浓度降低相关。在患有急性盆腔炎的女性中也看到了类似的变化。急性细菌性传播感染导致HIV-1病毒血症增加，这可能是通过增加炎性细胞因子或通过调节免疫反应来控制HIV-1病毒血症。
In Kenya, the median incubation time to AIDS in seroconverting sex workers is 4 years; this incubation time is specific to female sex workers. We studied the influence of acute sexually transmitted infections (STIs) on several immunologic parameters in 32 human immunodeficiency virus type 1 (HIV-1)-positive and 10 HIV-1-negative women sex workers who were followed for 1-5 months. Plasma cytokines, soluble cytokine receptors, CD4 and CD8 T cell counts, and HIV-1 plasma viremia were quantitated before, during, and after episodes of STI. Increases in interleukin (IL)-4, IL-6, IL-10, soluble tumor necrosis factor (TNF)-alpha, and viremia and a decline in CD4(+) T cell counts occurred during gonococcal cervicitis and returned to baseline after treatment. Increases in viremia correlated with increased IL-4 and decreased IL-6 concentrations. Similar changes were seen among women with acute pelvic inflammatory disease. Acute bacterial STI resulted in increased HIV-1 viremia, This may be mediated through increased inflammatory cytokines or through modulation of immune responses that control HIV-1 viremia.