A BEHAVIORALLY ACTIVE DOSE OF LIPOPOLYSACCHARIDE INCREASES SENSORY NEUROPEPTIDES LEVELS IN MOUSE SPINAL-CORD
A BEHAVIORALLY ACTIVE DOSE OF LIPOPOLYSACCHARIDE INCREASES SENSORY NEUROPEPTIDES LEVELS IN MOUSE SPINAL-CORD
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DOI：
10.1016/0304-3940(94)90184-8
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发表时间：
1994-05-23
影响因子：
2.5
通讯作者：
DANTZER, R
中科院分区：
文献类型：
--
作者：
BRETDIBAT, JL;KENT, S;DANTZER, R
为了评估外周免疫刺激是否在行为活性剂量下激活感觉传入，我们测量了脂多糖（LPS）对脊髓中感觉神经肽水平的影响。LPS（10 μ g/小鼠i. p.）增加脊髓中P物质、神经激肽A和降钙素基因相关肽的水平，注射后1小时观察到最大值。用吲哚美辛以一定剂量（5 mg/kg i. p.）完全阻断LPS诱导的食物动机行为的减少消除了这种作用。
To assess whether peripheral immune stimuli activate sensory afferents at behaviorally active doses, we measured the effects of lipopolysaccharide (LPS) on the levels of sensory neuropeptides in the spinal cord. LPS (10 mu g/mouse i.p.) increased the levels of substance P, neurokinin A, and calcitonin gene-related peptide in the spinal cord, the maximum being observed 1 hr post-injection. Pretreatment with indomethacin at a dose (5 mg/kg i.p.) which completely blocked the decrease in food-motivated behavior induced by LPS abrogated this effect.