Neurotoxic effects of ecstasy on the thalamus
Neurotoxic effects of ecstasy on the thalamus
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DOI：
10.1192/bjp.bp.106.035089
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发表时间：
2008-10-01
影响因子：
10.5
通讯作者：
van den Brink, Wim
中科院分区：
文献类型：
--
作者：
de Win, Maartje M. L.;Jager, Gerry;van den Brink, Wim
摇头丸的神经毒性作用已有报道，但尚不清楚这种作用是否可归因于摇头丸、其他娱乐性药物或这些药物的组合。可卡因和大麻作为荷兰XTC毒性（NeXT）研究的一部分。磁共振波谱、扩散张量成像、灌注加权成像和[（123）I]2 β-甲氧羰基-3 β-（4-碘苯基）-托烷（[（123）I]beta-CIT）单光子发射计算机断层扫描（5-羟色胺转运蛋白）在一个样本（n=71）与药物使用的广泛变化，结果Eclampin在丘脑中表现出特异性作用，[（123）I] β-CIT结合减少，提示β-CIT能轴突损伤，各向异性分数减少，提示轴突丢失;以及可能由血清素耗竭引起的脑血容量增加。摇头丸没有影响脑代谢产物和表观扩散coefficients. ConclusionsConvergingevidence被发现为一个特定的毒性作用摇头丸对丘脑中的肾上腺素能神经轴突。
BackgroundNeurotoxic effects of ecstasy have been reported, although it remains unclear whether effects can be attributed to ecstasy, other recreational drugs or a combination of these.AimsTo assess specific/independent neurotoxic effects of heavy ecstasy use and contributions of amphetamine, cocaine and cannabis as part of The Netherlands XTC Toxicity (NeXT) study.MethodEffects of ecstasy and other substances were assessed with (1)H-magnetic resonance spectroscopy, diffusion tensor imaging, perfusion weighted imaging and [(123)I]2 beta-carbomethoxy-3 beta-(4-iodophenyl)-tropane ([(123)I]beta-CIT) single photon emission computed tomography (serotonin transporters) in a sample (n=71) with broad variation in drug use, using multiple regression analyses.ResultsEcstasy showed specific effects in the thalamus with decreased [(123)I] beta-CIT binding, suggesting serotonergic axonal damage; decreased fractional anisotropy, suggesting axonal loss; and increased cerebral blood volume probably caused by serotonin depletion. Ecstasy had no effect on brain metabolites and apparent diffusion coefficients.ConclusionsConverging evidence was found for a specific toxic effect of ecstasy on serotonergic axons in the thalamus.