G-protein-coupled receptors: past, present and future
G-protein-coupled receptors: past, present and future
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DOI：
10.1038/sj.bjp.0706455
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发表时间：
2006-01-01
影响因子：
7.3
通讯作者：
Hill, SJ
中科院分区：
文献类型：
--
作者：
Hill, SJ
G蛋白偶联受体（GPCR）家族代表了最大和最通用的细胞表面受体组。对这些受体有活性的药物对从过敏性鼻炎到疼痛、高血压和精神分裂症的广泛的人类疾病具有治疗作用。这篇评论提供了一个简短的历史概述的属性和信号特征，这个重要的家庭的受体。
The G-protein-coupled receptor (GPCR) family represents the largest and most versatile group of cell surface receptors. Drugs active at these receptors have therapeutic actions across a wide range of human diseases ranging from allergic rhinitis to pain, hypertension and schizophrenia. This review provides a brief historical overview of the properties and signalling characteristics of this important family of receptors.