Synthesis and SAR of 3,5-diamino-piperidine derivatives: novel antibacterial translation inhibitors as aminoglycoside mimetics.
Synthesis and SAR of 3,5-diamino-piperidine derivatives: novel antibacterial translation inhibitors as aminoglycoside mimetics.
复制标题
3,5-二氨基哌啶衍生物的合成和SAR：作为氨基糖苷模拟物的新型抗菌翻译抑制剂。
DOI：
10.1016/j.bmcl.2006.12.024
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发表时间：
2007
影响因子：
2.7
通讯作者：
Wall,Daniel
中科院分区：
文献类型：
--
作者：
Zhou,Yuefen;Gregor,VladE;Ayida,BenjaminK;Winters,GeoffreyC;Sun,Zhongxiang;Murphy,Douglas;Haley,Greg;Bailey,Dwight;Froelich,JamieM;Fish,Sarah;Webber,StephenE;Hermann,Thomas;Wall,Daniel
氨基糖苷类抗生素靶向细菌核糖体解码位点内的内部RNA环。在这里，我们描述了新的3，5-二氨基哌啶衍生物作为氨基糖苷类模拟物的合成和SAR，并显示它们作为细菌翻译和生长的抑制剂。
Aminoglycoside antibiotics target an internal RNA loop within the bacterial ribosomal decoding site. Here, we describe the synthesis and SAR of novel 3,5-diamino-piperidine derivatives as aminoglycoside mimetics, and show they act as inhibitors of bacterial translation and growth.