Mutation bias and adaptation in bacteria.
Mutation bias and adaptation in bacteria.
复制标题
DOI：
10.1099/mic.0.001404
复制
发表时间：
2023-11
期刊：
影响因子：
2.8
通讯作者：
Taylor, Tiffany B.
中科院分区：
文献类型：
--
作者：
Horton, James S.;Taylor, Tiffany B.
关键词：
基因突变是进化适应的原材料，它在很大程度上是一种随机力量。然而，有充分的证据表明，突变也可以表现出强烈的偏见，一些突变类型和某些基因组位置比其他突变更频繁。越来越清楚的是，突变偏倚可以在实验室和临床上决定细菌的适应性结果中发挥作用。因此，了解突变偏差的原因和后果可以帮助微生物学家预测和预测适应性结果。在这篇综述中，我们提供了一个概述的机制和细菌基因组的特点，导致突变的偏见发生。然后，我们描述了驱动这些机制更加有效的环境触发因素，并概述了突变偏差可以与自然选择协同作用以定义进化结果的适应性情景。最后，我们描述了了解诱变基因组特征如何帮助微生物学家预测对突变偏倚敏感的区域，并概述了未来的工作，这将有助于我们实现更准确的进化预测。
Genetic mutation, which provides the raw material for evolutionary adaptation, is largely a stochastic force. However, there is ample evidence showing that mutations can also exhibit strong biases, with some mutation types and certain genomic positions mutating more often than others. It is becoming increasingly clear that mutational bias can play a role in determining adaptive outcomes in bacteria in both the laboratory and the clinic. As such, understanding the causes and consequences of mutation bias can help microbiologists to anticipate and predict adaptive outcomes. In this review, we provide an overview of the mechanisms and features of the bacterial genome that cause mutational biases to occur. We then describe the environmental triggers that drive these mechanisms to be more potent and outline the adaptive scenarios where mutation bias can synergize with natural selection to define evolutionary outcomes. We conclude by describing how understanding mutagenic genomic features can help microbiologists predict areas sensitive to mutational bias, and finish by outlining future work that will help us achieve more accurate evolutionary forecasts.
登录
查看更多内容
DOI：
10.1098/rstb.2022.0043
发表时间：
2023-05-22
影响因子：
6.3
作者：
Horton, James S. S.;Ali, Shani U. P.;Taylor, Tiffany B. B.
通讯作者：
Taylor, Tiffany B. B.
影响因子：
12.3
作者：
Blokzijl F;Janssen R;van Boxtel R;Cuppen E
通讯作者：
Cuppen E
影响因子：
16.6
作者：
Liu H;Zhang J
通讯作者：
Zhang J
DOI：
10.1098/rspb.2014.2698
发表时间：
2015-04-07
影响因子：
4.7
作者：
Couce, Alejandro;Rodriguez-Rojas, Alexandro;Blazquez, Jesus
通讯作者：
Blazquez, Jesus
影响因子：
3.3
作者：
Wilson BA;Petrov DA;Messer PW
通讯作者：
Messer PW