Fast atom bombardment mass spectrometric analysis of anthracyclines and anthracyclinones.
Fast atom bombardment mass spectrometric analysis of anthracyclines and anthracyclinones.
复制标题
蒽环类和蒽环类的快原子轰击质谱分析。
DOI：
10.1002/bms.1200170109
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
Desiderio,DM
中科院分区：
文献类型：
--
作者：
Dass,C;Seshadri,R;Israel,M;Desiderio,DM
A mass spectral characterization of a set of anthracyclines and anthracyclinones comprised of daunorubicin, adriamycin and their modified analogs was carried out by using negative and positive fast atom bombardment (FAB) ionization techniques. Addition of more than one hydrogen to the molecular ions of the anthracyclines was observed. The choice of the FAB matrix played an important role in the characterization of these compounds. The dominant ions in the molecular ion region were M−˙(or M+˙) and MH−(or ) when sulfolane and glycerol, respectively, were employed as the FAB solvents. The major fragmentation was cleavage of the glycosidic bond with the charge retention mainly on the aglycone moiety. Aromatization of the tetracyclic ring promoted further fragmentation of the aglycone moiety. The anthracyclinones could be characterized only by negative FAB ionization using sulfolane as the FAB matrix. The assigned fragmentation pathways were confirmed by acquiring metastable ion spectra usingB/Elinked‐field scans.
