Electro-acupuncture stimulation improves motor disorders in Parkinsonian rats
Electro-acupuncture stimulation improves motor disorders in Parkinsonian rats
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DOI：
10.1016/j.bbr.2009.06.024
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发表时间：
2009-12-14
影响因子：
2.7
通讯作者：
Wang, XiaoMin
中科院分区：
文献类型：
--
作者：
Jia, Jun;Sun, ZuoLi;Wang, XiaoMin
电针(EA)被认为对缓解帕金森氏症患者的运动症状有效。在单侧切断内侧前脑束(MFB)诱导的大鼠偏侧帕金森病模型上，观察了电针刺激的影响。高频(100赫兹)电针刺激显著降低阿朴吗啡诱导的旋转行为。酪氨酸羟化酶免疫组织化学染色显示，100 Hz电针对黑质多巴胺能神经元的变性有保护作用。高频电针可翻转切断轴突引起的中脑P物质含量下降和谷氨酸脱羧酶-67(GAD67)基因表达水平的升高，但不影响切断轴突引起的苍白球脑啡肽含量的升高。提示高频电针对帕金森病大鼠运动症状的影响可能与恢复基底节区多巴胺能传递的动态平衡有关。(C)2009爱思唯尔B.V.保留所有权利。
Electro-acupuncture (EA) is believed to be effective for alleviating motor symptoms in patients with Parkinson's disease. In a rat hemiparkinsonian model induced by unilateral transection of the medial forebrain bundle (MFB), the effects of EA stimulation were investigated. EA stimulation at a high frequency (100 Hz) significantly reduced apomorphine-induced rotational behavior. Tyrosine hydroxylase immunohistochemical staining revealed that EA at 100 Hz protected axotomized dopaminergic neurons from degeneration in the substantia nigra (SN). Moreover, high frequency EA reversed the axotomy-induced decrease in substance P content and increase in glutamate decarboxylase-67 (GAD 67) mRNA level in the midbrain; however, it did not affect the axotomy-induced increase in enkephalin content in the globus pallidus. These results suggest that the effects of high frequency EA on motor symptoms of Parkinsonian rats may involve restoration of the homeostasis of dopaminergic transmission in the basal ganglia circuit. (C) 2009 Elsevier B.V. All rights reserved.