QUANTITATIVE STUDY OF THE CELL POPULATION OF THE SEMINIFEROUS TUBULES IN IMMATURE RATS
QUANTITATIVE STUDY OF THE CELL POPULATION OF THE SEMINIFEROUS TUBULES IN IMMATURE RATS
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DOI：
10.1002/aja.1001000205
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发表时间：
1957-01-01
影响因子：
--
通讯作者：
PEREY, B
中科院分区：
文献类型：
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作者：
CLERMONT, Y;PEREY, B
对大鼠从胎儿晚期到成熟期的性索和曲细精管进行了组织学描述，并通过收集细胞数量的数据完成了描述。e.支持细胞、生殖细胞和/或其后代。计数结果表明，支持细胞在出生时及出生后不久增殖活跃，15日龄时停止分裂，45日龄时成为典型的支持细胞。一些生殖母细胞在4天大鼠中开始增殖，并产生A型精原细胞。然而，许多生殖细胞不能分裂和退化。在6天大鼠中，A型细胞又增殖并产生新的A型细胞（干细胞，在以后的时间间隔内提供新一代精原细胞的形成）和B型细胞，B型细胞又产生精母细胞。到第15天，每个A型细胞的精母细胞产量与成人的估计值相同。这表明，当A型精原细胞出现时，即早在出生后4天，就开始了数量上正常的精子发生。在第15天，很明显，类似于在成人中观察到的生精spithelium的周期性变化已经建立。据推测，周期开始于A型精原细胞开始增殖，从一开始，周期的持续时间约为成人的10天。
A histological description of the sex cords and seminiferous tubules of rats from late fetal life to maturity was carried out and completed by collecting data on the number of cells present, i. e. supporting cells, gonocytes and/or their progeny. The counts reveal that the supporting cells proliferate actively at and soon after birth, stop dividing in 15-day rats and become typical Sertoli elements in 45-day animals. Some gonocytes start proliferating in 4-day rats and give rise to type A spermatogonia. However, many gonocytes fail to divide and degenerate. In 6-day rats the type A cells in turn proliferate and give rise to new type A cells (stem cells which at later time intervals provided for the formation of new generations of spermatogonia) and to type B cells which in turn produce spermatocytes. By the 15th day the yield of spermatocytes per type A cell is identical to that estimated in the adult. This indicates that a quantitatively normal spermatogenesis is initiated as type A spermatogonia appear, that is, as early as 4 days after birth. On the 15th day it becomes evident that cyclic changes of the seminiferous spithelium similar to those observed in the adult are already established. Presumably the cycle begins as type A spermatogonia start proliferating, and, from the start, the duration of the cycle approximates 10 days as in the adult.