Diagnostic and prognostic imaging of the cardiac sympathetic nervous system
Diagnostic and prognostic imaging of the cardiac sympathetic nervous system
复制标题
心脏交感神经系统的诊断和预后成像
DOI：
--
复制
发表时间：
2008
期刊：
影响因子：
--
通讯作者：
J. Caldwell
中科院分区：
文献类型：
--
作者：
J. Link;J. Caldwell
患有收缩功能障碍充血性心力衰竭的个体可能具有神经元密度降低、神经元功能降低（去甲肾上腺素的再摄取或保留）或这些的组合，加上突触后β受体密度降低。心脏神经元分布和功能可以用标准γ照相机和PET使用去甲肾上腺素的放射性标记类似物成像。突触后β-肾上腺素能受体分布和密度可以使用PET来确定。突触前成分的多项成像研究报道，放射性标记类似物保留最低或洗脱最快的个体的年死亡率比保留更高或洗脱速度更慢的个体高得多。一些研究的结果表明，与射血分数、心率变异性和微伏T波电交替等更常见的结局预测因子相比，影像异常是更好的死亡预测因子。这些研究之间的差异性使得不清楚哪种突触前功能障碍的测量是最具预测性的。β受体成像作为预后工具的评价不如突触前成像广泛。初步数据表明，β受体和突触前去甲肾上腺素转运蛋白功能之间的区域错配可能是不良结局的标志。
Individuals with systolic dysfunction congestive heart failure may have decreased neuronal density, decreased neuronal function (reuptake or retention of norepinephrine), or a combination of these, plus reduction in postsynaptic β-receptor density. Cardiac neuronal distribution and function can be imaged with standard γ cameras and PET using radiolabeled analogs of norepinephrine. Postsynaptic β-adrenergic receptor distribution and density can be determined using PET. Multiple imaging studies of the presynaptic component have reported that those individuals with the lowest retention or fastest washout of the radiolabeled analogs have a much greater annual mortality than do those with greater retention or slower washout rate. The results of some studies have suggested that the image abnormalities are better predictors of death than are more common predictors of outcome such as ejection fraction, heart rate variability, and microvolt T-wave alternans. The variability between these studies makes it unclear which measure of presynaptic dysfunction is the most predictive. β-Receptor imaging has not been evaluated as extensively as a prognostic tool as has presynaptic imaging. Preliminary data suggest that regional mismatch between β-receptors and presynaptic norepinephrine transporter function may serve as a marker for adverse outcome.
登录
查看更多内容
影响因子：
37.8
作者：
M. Schwaiger;V. Kalff;K. Rosenspire;M. Haka;E. Molina;G. Hutchins;Michael G. Deeb;E. Wolfe;D. Wieland
通讯作者：
M. Schwaiger;V. Kalff;K. Rosenspire;M. Haka;E. Molina;G. Hutchins;Michael G. Deeb;E. Wolfe;D. Wieland
DOI：
10.1016/s0026-0495(99)90016-1
发表时间：
1999
期刊：
Metabolism: clinical and experimental
影响因子：
--
作者：
M. Stevens;M. Stevens;D. Raffel;D. Raffel;K. Allman;K. Allman;M. Schwaiger;M. Schwaiger;D. Wieland;D. Wieland
通讯作者：
M. Stevens;M. Stevens;D. Raffel;D. Raffel;K. Allman;K. Allman;M. Schwaiger;M. Schwaiger;D. Wieland;D. Wieland
影响因子：
20.1
作者：
BRISTOW, MR;GINSBURG, R;STINSON, EB
通讯作者：
STINSON, EB
PET 测量突触前和突触后心脏 β 肾上腺素能功能。
影响因子：
3.1
作者：
Link,JeanneM;Stratton,JohnR;Levy,Wayne;Poole,JeanneE;Shoner,StevenC;Stuetzle,Werner;Caldwell,JamesH
通讯作者：
Caldwell,JamesH