Tissue inhibitor of metalloproteinases-1 in the postoperative monitoring of colorectal cancer
Tissue inhibitor of metalloproteinases-1 in the postoperative monitoring of colorectal cancer
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DOI：
10.1016/j.ejca.2006.01.058
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发表时间：
2006-08-01
影响因子：
8.4
通讯作者：
Christensen, Ib Jarle
中科院分区：
文献类型：
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作者：
Holten-Andersen, Mads Nikolaj;Nielsen, Hans Jorgen;Christensen, Ib Jarle
本研究旨在探讨结直肠癌（CRC）患者术前和术后血浆金属蛋白酶组织抑制剂-1（TIMP-1）水平与结直肠癌预后的关系。对280例根治性切除的CRC患者术前和术后血浆TIMP-1和相应血清样本中的癌胚抗原（CEA）进行了测定，并与患者结局（死亡、局部复发（LR）和远处转移（DM））进行了相关性分析。结果显示，血浆TIMP-1从术前到术后水平的变化与患者结局相关（P = 0.005）。然而，术后血浆TIMP-1单独与患者结局密切相关，TIMP-1高预示生存期短（P = 0.002）。联合术后TIMP-1和CEA显示高TIMP-1和CEA水平预测预后不良（P < 0.0001）;多变量分析表明这两个参数是生存、LR和DM的强预后因素（P < 0.0001）。总之，术后血浆TIMP-1可单独或与CEA联合预测患者预后。术后TIMP-1可能是结直肠癌初次手术后残留病变的标志物。
The aim of this study was to investigate whether the pre- and postoperative plasma levels of tissue inhibitor of metalloproteinases-1 (TIMP-1) were associated with outcome in colorectal cancer (CRC). Pre- and postoperative plasma TIMP-1 from 280 curatively resected CRC patients and carcinoembryonic antigen (CEA) in corresponding serum samples were measured and correlated with patient outcome (death, local recurrence (LR) and distant metastases (DM)). The results showed that the course of plasma TIMP-1 from pre- to postoperative levels correlated with patient outcome (P = 0.005). However, postoperative plasma TIMP-1 alone was strongly associated with patient outcome, high TIMP-1 predicting short survival (P = 0.002). Combining postoperative TIMP-1 and CEA demonstrated that high TIMP-1 and CEA levels predicted poor outcome (P < 0.0001); multivariate analysis identifying both parameters as strong prognostic factors for survival, LR and DM (P < 0.0001). In conclusion, postoperative plasma TIMP-1 predicts patient outcome both alone and in combination with CEA. Postoperative TIMP-1 may be a marker of residual disease after primary surgery for CRC.