Novel therapeutic agents for cutaneous T-Cell lymphoma.

Novel therapeutic agents for cutaneous T-Cell lymphoma.
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DOI:
10.1186/1756-8722-5-24
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发表时间:
2012-05-17
影响因子:
28.5
通讯作者:
O'Connor O
O'Connor O
中科院分区:
医学1区
文献类型:
--
作者:
Jain S;Zain J;O'Connor O

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蕈样肉芽肿 (MF) 和塞扎里综合征 (SS) 是原发性皮肤 T 细胞淋巴瘤 (CTCL) 最常见的亚型。晚期 MF 和 SS 患者的预后较差,因此人们对开发具有针对性作用机制和可接受的安全性的新疗法产生了兴趣。在这篇综述中,我们重点关注改变这种罕见恶性肿瘤治疗模式的新策略。
Mycosis fungoides (MF) and Sezary Syndrome (SS) represent the most common subtypes of primary Cutaneous T-cell lymphoma (CTCL). Patients with advanced MF and SS have a poor prognosis leading to an interest in the development of new therapies with targeted mechanisms of action and acceptable safety profiles. In this review we focus on such novel strategies that have changed the treatment paradigm of this rare malignancy.
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