Nitric oxide production inhibitory activity of flavonoids contained in trunk exudates of Dalbergia sissoo
Nitric oxide production inhibitory activity of flavonoids contained in trunk exudates of Dalbergia sissoo
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DOI：
10.1021/np070478h
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发表时间：
2008-01-01
影响因子：
5.1
通讯作者：
Takeda, Tadahiro
中科院分区：
文献类型：
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作者：
Shrestha, Suraj Prakash;Arnano, Yuri;Takeda, Tadahiro
Dalbergia sissoo 树干分泌物的甲醇提取物产生了两种新的开链新黄酮类化合物 (1, 2)、一种新的黄酮类化合物 (3)、一种新的黄烷酮 (4) 和 26 种已知化合物。通过详细的光谱分析阐明了它们的结构。还研究了分离的化合物阻止 LPS 刺激的 J774.1 细胞产生一氧化氮 (NO) 的能力。除4、芒柄花素和zenognosin B 外，所有分离的化合物都以浓度依赖性方式表现出显着的活性。化合物2和3是最有效的NO产生抑制剂，IC50值分别为3.19和6.22μM，化合物1的IC50为31.6μM。
Methanolic extracts of trunk exudates of Dalbergia sissoo yielded two new open-chain neoflavonoids (1, 2), a new flavonoid (3), a new flavanone (4), and 26 known compounds. Their structures were elucidated by detailed spectroscopic analyses. The ability of the isolated compounds to prevent nitric oxide (NO) production by LPS-stimulated J774.1 cells was also studied. All of the isolated compounds except 4, formononetin, and zenognosin B exhibited significant activity in a concentration-dependent manner. Compounds 2 and 3 were among the most potent NO production inhibitors, with IC50 values of 3.19 and 6.22 mu M, respectively, and compound 1 had an IC50 of 31.6 mu M.