Synergism in novel silver-copper/hydroxyapatite composites for increased antibacterial activity and biocompatibility
Synergism in novel silver-copper/hydroxyapatite composites for increased antibacterial activity and biocompatibility
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DOI：
10.1016/j.ceramint.2020.05.102
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发表时间：
2020-08
影响因子：
5.2
通讯作者：
Nabor Oswvaldo Martínez-Gracida;S. C. Esparza-González;N. A. Castillo-Martínez;A. Serrano-Medina;Imelda Olivas-Armendáriz;L. G. Campos-Múzquiz;E. Múzquiz-Ramos
中科院分区：
文献类型：
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作者：
Nabor Oswvaldo Martínez-Gracida;S. C. Esparza-González;N. A. Castillo-Martínez;A. Serrano-Medina;Imelda Olivas-Armendáriz;L. G. Campos-Múzquiz;E. Múzquiz-Ramos
This study develops a novel silver-copper/hydroxyapatite composite (Ag–Cu/HA) with high biocompatibility and antibacterial activity. Two different materials were synthesized, namely silver-hydroxyapatite (Ag-HA) and copper-hydroxyapatite (Cu-HA) composites, with 0.1%, 0.5%, and 1.0% (mol) of each metal. These materials were mixed in a planetary mill to obtain the Ag–Cu/HA composites. The results of our characterization demonstrated the low cytotoxicity and hemolytic response. The composite showed higher percent-inhibition for bacterial growth compared to those in separated composites of silver or copper with hydroxyapatite. Hence, these new materials promise higher efficacy as antibacterial hydroxyapatites.
