Synthetic carbohydrate-based HIV-1 vaccines.
Synthetic carbohydrate-based HIV-1 vaccines.
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DOI：
10.1016/j.ddtec.2020.09.004
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发表时间：
2020-12-01
期刊：
影响因子：
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通讯作者：
Fernandez-Tejada, Alberto
中科院分区：
文献类型：
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作者：
Bastida, Inaki;Fernandez-Tejada, Alberto
有效的预防性HIV-1疫苗对于遏制艾滋病毒/艾滋病的全球流行至关重要。在过去的几十年中，不同的广泛中和抗体（bnAb）的发现使得能够表征HIV包膜（Env）刺突上的几个最小表位，包括聚糖依赖性片段。在此，我们提供了一个简要的概述上的开发合成的碳水化合物为基础的表位模拟物的bnAbs针对Env gp 120蛋白的某些区域的启发：外结构域高甘露糖簇和可变环V1 V2和V3的进展。我们专注于最小免疫原的设计，合成和生物学评价，并讨论了成功开发HIV-1保护性疫苗的关键方面。
An effective prophylactic HIV-1 vaccine is essential in order to contain the HIV/AIDS global pandemic. The discovery of different broadly neutralizing antibodies (bnAbs) in the last decades has enabled the characterization of several minimal epitopes on the HIV envelope (Env) spike, including glycan-dependent fragments. Herein, we provide a brief overview of the progress made on the development of synthetic carbohydrate-based epitope mimics for the elicitation of bnAbs directed to certain regions on Env gp120 protein: the outer domain high-mannose cluster and the variable loops V1V2 and V3. We focus on the design, synthesis and biological evaluation of minimal immunogens and discuss key aspects towards the development of a successful protective vaccine against HIV-1.