ABSENCE OF CONTRAST ENHANCEMENT ON CT BRAIN-SCANS OF PATIENTS WITH SUPRATENTORIAL MALIGNANT GLIOMAS
ABSENCE OF CONTRAST ENHANCEMENT ON CT BRAIN-SCANS OF PATIENTS WITH SUPRATENTORIAL MALIGNANT GLIOMAS
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DOI：
10.1212/wnl.38.9.1371
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发表时间：
1988-09-01
期刊：
影响因子：
9.9
通讯作者：
LEVIN, VA
中科院分区：
文献类型：
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作者：
CHAMBERLAIN, MC;MUROVIC, JA;LEVIN, VA
回顾了229例幕上恶性胶质瘤患者的病历，包括组织学、诊断时的年龄、肿瘤位置和手术时给予造影剂后获得的CT增强模式。在93例多形性胶质母细胞瘤（GM）患者中有4例（4%），10例Gemistocytic星形细胞瘤（GA）患者中有3例（30%），74例高度间变性星形细胞瘤（HAA）患者中有23例（31%），52例中度间变性星形细胞瘤（MoAA）患者中有28例（54%）。不同胶质瘤组织类型（增强型和非增强型）的年龄相关发病率反映在诊断时的中位年龄：GM 50岁，GA 52岁，HAA 40岁，MoAA 34岁。GM、GA和MoAA患者的年龄和CT对比增强模式相似;无增强哈斯患者在就诊时往往更年轻。除MoAA外，所有组的肿瘤位置和增强和非增强病变的频率相似，其中非增强肿瘤最常见于额颞叶，增强肿瘤通常为额顶叶。我们的研究结果表明，重要的是要获得组织学确诊的幕上胶质瘤患者的诊断，无论存在或不存在的对比增强的肿瘤CT，因为这些特征与肿瘤的组织学。
The medical records of 229 consecutive patients with supratentorial malignant gliomas were reviewed with respect to histology, age at diagnosis, tumor location, and enhancement pattern on the CT obtained after the administration of contrast material at the time of operation. Nonenhancing tumors were identified in four (4%) of 93 patients with glioblastoma multiforme (GM), three (30%) of ten with gemistocytic astrocytoma (GA), 23 (31%) of 74 with highly anaplastic astrocytoma (HAA), and 28 (54%) of 52 with moderately anaplastic astrocytoma (MoAA). The age-related incidence of the various glioma histiotypes (both enhancing and nonenhancing) was reflected by the median age at diagnosis: 50 years in GM, 52 years in GA, 40 years in HAA, and 34 years in MoAA. The age and CT contrast enhancement pattern were similar in patients with GM, GA, and MoAA; patients with nonenhancing HAAs tended to be younger at presentation. The tumor location and the frequency of enhancing and nonenhancing lesions were similar for all groups except MoAA, in which nonenhancing tumors were most often frontotemporal and enhancing tumors were usually frontoparietal. Our results demonstrate that it is important to obtain histologic confirmation of the diagnosis in patients with supratentorial gliomas regardless of the presence or absence of contrast enhancement of the tumor on CT, because of these characteristics correlates with the tumor histology.