EXPRESSION OF CD44 IN PROSTATE-CANCER CELLS
EXPRESSION OF CD44 IN PROSTATE-CANCER CELLS
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DOI：
10.1016/0304-3835(94)90135-x
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发表时间：
1994-01-15
期刊：
影响因子：
9.7
通讯作者：
LIU, AY
中科院分区：
文献类型：
--
作者：
LIU, AY
研究了人前列腺细胞系中细胞透明质酸受体CD44的表达。CD44 mRNA在前列腺腺癌器官转移的PC3和DU145细胞系中检测到，但在淋巴结转移的LNCaP细胞系中未检测到。PC3和DU145在裸鼠中具有致瘤性和转移性，而LNCaP没有。在已鉴定的CD44 mRNA物种中，代表了标准CD44s以及变异同种异构体CD44v7、CD44v10、CD44v14、CD44v13-v14、CD44v12-v14和CD44v7-v14。
Expression of CD44, the cellular hyaluronate receptor, was examined in human prostate cell lines. CD44 mRNA was detected in cell lines PC3 and DU145, both established from organ metastases of prostate adenocarcinoma, but not in cell line LNCaP, established from a lymph node metastasis. PC3 and DU145, but not LNCaP, are tumorigenic and metastatic in nude mice. Of the CD44 mRNA species identified, the standard CD44s as well as variant isoforms CD44v7, CD44v10, CD44v14, CD44v13-v14, CD44v12-v14 and CD44v7-v14 are represented.