β-estradiol 3-benzoate affects spermatogenesis in the adult mouse
β-estradiol 3-benzoate affects spermatogenesis in the adult mouse
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β-雌二醇3-苯甲酸酯影响成年小鼠的精子发生
DOI：
10.1016/s0303-7207(01)00419-1
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发表时间：
2001
影响因子：
4.1
通讯作者：
S. Yuasa
中科院分区：
文献类型：
--
作者：
Y. Toyama;I. Hosoi;Souichirou Ichikawa;M. Maruoka;Eiko Yashiro;Haruo Ito;S. Yuasa
β-3-苯甲酸雌二醇酯(E2b)(10、16、20、40、80和160μg/kg体重)每日给药，持续2、3天、1、2、4和8周。光镜和电子显微镜下观察睾丸的形态变化。生精小管腔内可见生殖细胞脱落。生精周期紊乱，尤其是第XII期。步骤6以上的精子细胞受到严重影响。精子细胞的异常表现为细胞核和顶体变形。支持-精子细胞外质特化的部分缺失也被观察到。低于STEP 7精子细胞的生殖细胞在形态上不受影响。在服用低于16μg/kg体重的化学物质的小鼠中，没有检测到这些异常。结果表明，该化学物质对圆形精子细胞有代谢作用，但其形态效应仅见于6龄以上的精子细胞，对成年小鼠的作用是可逆的。
β-estradiol 3-benzoate (E2B) (10, 16, 20, 40, 80 and 160 μg/kg body weight) was administered daily to experimental groups of adult mice for the following periods; 2, 3 days, 1, 2, 4, and 8 weeks. Morphological changes in the testes were observed by both light and electron microscopy. Exfoliation of the germ cells was observed in the lumen of the seminiferous tubule. The spermatogenic cycle, especially stage XII, was disordered. Spermatids older than step 6 were severely affected. Detected abnormalities in the spermatids were deformation of the nucleus and acrosome. Partial deletion in the Sertoli-spermatid ectoplasmic specialization was also observed. Germ cells younger than step 7 spermatids were not affected morphologically. These abnormalities were not detected in the mice treated with the chemical at less than 16 μg/kg body weight. It is concluded that the chemical seems to affect round spermatids metabolically, but the morphological effect can be detected only from the spermatids older than step 6. The effects of the chemical on adult mice were reversible.
DOI：
10.1073/pnas.95.26.15677
发表时间：
1998-12-22
影响因子：
11.1
作者：
Krege, JH;Hodgin, JB;Smithies, O
通讯作者：
Smithies, O
非洲爪蟾雌激素受体：与人类和鸟类受体的序列同源性以及多种雌激素受体信使核糖核酸的鉴定。
DOI：
10.1210/mend-1-5-355
发表时间：
1987
期刊：
Molecular endocrinology (Baltimore, Md.)
影响因子：
--
作者：
Weiler,IJ;Lew,D;Shapiro,DJ
通讯作者：
Shapiro,DJ
DOI：
10.1073/pnas.90.23.11162
发表时间：
1993-12-01
影响因子：
11.1
作者：
LUBAHN, DB;MOYER, JS;SMITHIES, O
通讯作者：
SMITHIES, O