Dynamic enhanced CT: is there a difference between liver metastases of gastroenteropancreatic neuroendocrine tumor and adenocarcinoma
Dynamic enhanced CT: is there a difference between liver metastases of gastroenteropancreatic neuroendocrine tumor and adenocarcinoma
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DOI：
10.18632/oncotarget.22554
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发表时间：
2017-12-08
期刊：
影响因子：
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通讯作者：
Sun, Ying-Shi
中科院分区：
文献类型：
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作者：
Cui, Yong;Li, Zhong-Wu;Sun, Ying-Shi
本研究拟根据胃肠胰腺高分化神经内分泌肿瘤（GEP NETs）肝转移的特征性表现，评价动态增强CT鉴别GEP NETs肝转移与GEP腺癌的可行性。回顾性分析23例高分化（G1或G2）GEP NETs和23例GEP腺癌伴肝转移患者的CT图像。主观分析肿瘤的分布类型、形态、肿瘤内新生血管、肝动脉期强化、动态增强模式及淋巴结肿大情况。同时测量肿瘤及邻近正常肝实质的大小、数目、CT值，客观计算肝转移率。与GEP腺癌相比，GEP NETs肝转移瘤在肝动脉期呈高强化，动态增强模式为洗脱型，无淋巴结肿大，肝动脉期和门静脉期转移瘤占肝的比例均较高（P= 0.017，P
This study proposed to evaluate the feasibility of dynamic enhanced CT in differentiation of liver metastases of gastroenteropancreatic well-differentiated neuroendocrine tumors (GEP NETs) from GEP adenocarcinomas based on their characteristic features. CT images of 23 well-differentiated (G1 or G2) GEP NETs and 23 GEP adenocarcinomas patients with liver metastases were retrospectively reviewed. The distribution type, shape, intra-tumoral neovascularity, enhancement on hepatic artery phase, dynamic enhancement pattern and lymphadenopathy were subjective analyzed. Meanwhile, the size, number, CT value of tumor and adjacent normal liver parenchyma were measured and the metastasis-to-liver ratios were calculated objectively. Compared with GEP adenocarcinomas, the liver metastases of GEP NETs more frequently demonstrated a hyper enhancement on hepatic artery phase, washout dynamic enhancement pattern, absence of lymphadenopathy and higher metastasis-to-liver ratios on both hepatic artery phase and portal venous phase (P=0.017, P