Altered serotonin transporter sites in Alzheimer's disease raphe and hippocampus.
Altered serotonin transporter sites in Alzheimer's disease raphe and hippocampus.
复制标题
阿尔茨海默病中缝和海马中血清素转运蛋白位点的改变。
DOI：
10.1097/00001756-199505300-00033
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发表时间：
1995
期刊：
影响因子：
1.7
通讯作者：
Pawlyk,AC
中科院分区：
文献类型：
--
作者：
Tejani-Butt,SM;Yang,J;Pawlyk,AC
本研究测定了阿尔茨海默病（AD）中缝背核（DRN）和海马中5-羟色胺转运体（5-HTT）的位点。5-AD患者DRN的HTT位点显著减少，DRN复合体的侧翼显著减少。AD患者海马CA 2区和内嗅皮质5-HTT位点也明显减少。结果表明，在DRN的5-HT神经元的完整性可能会受到损害，在AD的海马复合体5-HTT位点的区域特异性改变可能会发生在AD。
This study measured serotonin transporter (5-HTT) sites in the dorsal raphe nucleus (DRN) and hippocampus in Alzheimer's disease (AD). 5-HTT sites were significantly decreased in the DRN in AD, with significant reductions occurring in the lateral wings of the DRN complex. A significant reduction in 5-HTT sites were also observed in the CA 2 subfield of the hippocampus and in the entorhinal cortex in AD. The results indicate that the integrity of 5-HT neurons in the DRN may be compromised in AD, and that region specific alterations in 5-HTT sites may occur in the hippocampal complex in AD.