A Mixed-Signal VLSI System for Producing Temporally Adapting Intraspinal Microstimulation Patterns for Locomotion.
A Mixed-Signal VLSI System for Producing Temporally Adapting Intraspinal Microstimulation Patterns for Locomotion.
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DOI：
10.1109/tbcas.2015.2501419
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发表时间：
2016-08
影响因子：
5.1
通讯作者：
Etienne-Cummings R
中科院分区：
文献类型：
--
作者：
Mazurek KA;Holinski BJ;Everaert DG;Mushahwar VK;Etienne-Cummings R
神经通路可以通过使用电刺激来人工激活。对于脊髓损伤的个体，使用125 μA量级的电流进行脊柱内微刺激可以在下肢产生适合于恢复行走的肌肉收缩和关节扭矩。这里介绍的工作演示了一个集成电路实现基于状态的控制策略，其中感觉反馈和固有前馈控制形状的刺激波形片上产生的。该器件采用0.5 μm工艺制造，成功地在体内用于在脊髓损伤模型中产生行走运动。这项工作代表了一种用于恢复脊髓损伤患者行走的可植入解决方案的进展。
Neural pathways can be artificially activated through the use of electrical stimulation. For individuals with a spinal cord injury, intraspinal microstimulation, using electrical currents on the order of 125 μA, can produce muscle contractions and joint torques in the lower extremities suitable for restoring walking. The work presented here demonstrates an integrated circuit implementing a state-based control strategy where sensory feedback and intrinsic feed forward control shape the stimulation waveforms produced on-chip. Fabricated in a 0.5 μm process, the device was successfully used in vivo to produce walking movements in a model of spinal cord injury. This work represents progress towards an implantable solution to be used for restoring walking in individuals with spinal cord injuries.