ROLE OF TISSUE FACTOR IN DISSEMINATED INTRAVASCULAR COAGULATION
ROLE OF TISSUE FACTOR IN DISSEMINATED INTRAVASCULAR COAGULATION
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DOI：
10.1016/0049-3848(95)00170-v
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发表时间：
1995-11-01
影响因子：
7.5
通讯作者：
MATSUDA, T
中科院分区：
文献类型：
--
作者：
ASAKURA, H;KAMIKUBO, Y;MATSUDA, T
本文检测了95例弥散性血管内凝血（DIC）患者血浆组织因子（TF）抗原水平，以探讨TF在DIC中的作用。在与癌症相关的DIC病例中观察到TF血浆抗原水平显著升高。然而，在急性早幼粒细胞白血病（APL）、急性白血病（APL除外）、慢性粒细胞白血病急变、非霍奇金淋巴瘤（NHL）、败血症和暴发性肝炎相关DIC病例中，未观察到这种显著升高。除4例恶性肿瘤患者发生DIC外，其余无DIC者TF均无明显升高。DIC合并肾功能衰竭和慢性肾功能衰竭不伴DIC者血浆TF抗原水平均高于无肾功能衰竭者。因此，血浆TF抗原水平在DIC合并肾功能衰竭患者被认为是仔细估计。部分DIC患者TF水平随临床症状改善而下降，而DIC无改善者TF水平进一步升高或维持在较高水平。因此，血浆TF抗原水平是预测DIC发展和/或预后的重要标志物，特别是在癌症患者中。
We examined plasma antigen levels of tissue factor (TF) in 95 cases of disseminated intravascular coagulation (DIC), to investigate the role of TF in DIC. A significant elevation of plasma antigen levels of TF was observed in cases of DIC associated with cancer. However, no such significant elevation was observed in cases of DIC associated with acute promyelocytic leukemia (APL), acute leukemia except APL, blastic crisis of chronic myelogenous leukemia, non-Hodgkin lymphoma (NHL), sepsis or fulminant hepatitis. No significant elevation of TF was observed in patients without DIC, except 4 cases of cancer who developed DIC thereafter. Plasma antigen levels of TF were higher in bath cases of DIC with renal failure and chronic renal failure without DIC than its levels in those without renal failure. Therefore,plasma antigen levels of TF in DIC patients with renal failure were considered to be carefully estimated. The levels of TF were decreased with the clinical improvement in some cases of DIC but were further increased or remained at high levels in patients who showed no improvement of DIC. Thus, plasma antigen levels of TF is an important marker to predict the development and/or prognosis of DIC, especially in patients with cancer.