Fish oil intake induces UCP1 upregulation in brown and white adipose tissue via the sympathetic nervous system.
Fish oil intake induces UCP1 upregulation in brown and white adipose tissue via the sympathetic nervous system.
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DOI：
10.1038/srep18013
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发表时间：
2015-12-17
影响因子：
4.6
通讯作者：
Kawada T
中科院分区：
文献类型：
--
作者：
Kim M;Goto T;Yu R;Uchida K;Tominaga M;Kano Y;Takahashi N;Kawada T
棕色脂肪组织（BAT）在调节能量平衡中起着重要作用，并可能为人类肥胖的治疗提供新的策略。BAT介导的产热在经典棕色和异位米色脂肪细胞中受线粒体解偶联蛋白1（UCP 1）调节，并受交感神经系统（SNS）控制。先前的研究表明，鱼油摄入减少了脂肪积累，并诱导UCP 1在BAT中的表达;然而，这种作用的详细机制仍不清楚。在这项研究中，我们研究了鱼油对能量消耗和SNS的影响。鱼油摄入增加了耗氧量和直肠温度，同时上调了UCP 1和β3肾上腺素能受体（β 3 AR），这是肩胛间BAT和腹股沟白色脂肪组织（WAT）中米色脂肪细胞的两个标志物。此外，鱼油摄入量增加消除尿儿茶酚胺和去甲肾上腺素（NA）周转率在肩胛间BAT和腹股沟WAT。此外，鱼油对SNS介导的能量消耗的影响在瞬时受体电位香草素1（TRPV 1）基因敲除小鼠中被消除。总之，鱼油摄入可以通过SNS诱导经典棕色和米色脂肪细胞中的UCP 1表达，从而减少脂肪积累并改善脂质代谢。
Brown adipose tissue (BAT) plays a central role in regulating energy homeostasis, and may provide novel strategies for the treatment of human obesity. BAT-mediated thermogenesis is regulated by mitochondrial uncoupling protein 1 (UCP1) in classical brown and ectopic beige adipocytes, and is controlled by sympathetic nervous system (SNS). Previous work indicated that fish oil intake reduces fat accumulation and induces UCP1 expression in BAT; however, the detailed mechanism of this effect remains unclear. In this study, we investigated the effect of fish oil on energy expenditure and the SNS. Fish oil intake increased oxygen consumption and rectal temperature, with concomitant upregulation of UCP1 and the β3 adrenergic receptor (β3AR), two markers of beige adipocytes, in the interscapular BAT and inguinal white adipose tissue (WAT). Additionally, fish oil intake increased the elimination of urinary catecholamines and the noradrenaline (NA) turnover rate in interscapular BAT and inguinal WAT. Furthermore, the effects of fish oil on SNS-mediated energy expenditure were abolished in transient receptor potential vanilloid 1 (TRPV1) knockout mice. In conclusion, fish oil intake can induce UCP1 expression in classical brown and beige adipocytes via the SNS, thereby attenuating fat accumulation and ameliorating lipid metabolism.