Future needs and recommendations in the development of species sensitivity distributions: Estimating toxicity thresholds for aquatic ecological communities and assessing impacts of chemical exposures
Future needs and recommendations in the development of species sensitivity distributions: Estimating toxicity thresholds for aquatic ecological communities and assessing impacts of chemical exposures
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DOI：
10.1002/ieam.1841
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发表时间：
2017-07-01
影响因子：
3.1
通讯作者：
Whitehouse, Paul
中科院分区：
文献类型：
--
作者：
Belanger, Scott;Barron, Mace;Whitehouse, Paul
物种敏感性分布（SSD）是物种对应激源（特别是化学暴露）敏感性变化的概率模型。自20世纪80年代以来，SSD方法一直被用作环境保护和管理的决策支持工具，生态毒理学，统计和监管基础和应用继续发展。本文总结了由欧洲化学品毒理学和生态毒理学中心和英国环境署在荷兰阿姆斯特丹举行的2014年研讨会的结果，讨论了SSD的生态相关性，统计基础和监管应用。一系列的研究建议分类下的主题领域的使用SSD，生态考虑，指南考虑，方法开发和验证，毒性数据，机械的理解，和不确定性进行了确定和优先级。为讲习班中确定的最关键的研究需求提供了理由。研讨会审查了安全性数据集的技术基础和历史发展及应用，介绍了估计基于安全性数据集的通用和特定区域安全性数据集阈值的方法，评价了安全性数据集作为诊断工具的效用和应用，并介绍了制定安全性数据集的新统计方法。总的来说，这些解决了许多研究需求，以扩大和改善其应用。从务实的监管角度来看，最优先的工作是制定最佳做法指南，作为全球统一和讨论SSD方法和工具的基础。Integr Environ Assess Manag 2017;13：664-674. (c)2016年SETAC
A species sensitivity distribution (SSD) is a probability model of the variation of species sensitivities to a stressor, in particular chemical exposure. The SSD approach has been used as a decision support tool in environmental protection and management since the 1980s, and the ecotoxicological, statistical, and regulatory basis and applications continue to evolve. This article summarizes the findings of a 2014 workshop held by the European Centre for Toxicology and Ecotoxicology of Chemicals and the UK Environment Agency in Amsterdam, The Netherlands, on the ecological relevance, statistical basis, and regulatory applications of SSDs. An array of research recommendations categorized under the topical areas of use of SSDs, ecological considerations, guideline considerations, method development and validation, toxicity data, mechanistic understanding, and uncertainty were identified and prioritized. A rationale for the most critical research needs identified in the workshop is provided. The workshop reviewed the technical basis and historical development and application of SSDs, described approaches to estimating generic and scenario-specific SSD-based thresholds, evaluated utility and application of SSDs as diagnostic tools, and presented new statistical approaches to formulate SSDs. Collectively, these address many of the research needs to expand and improve their application. The highest priority work, from a pragmatic regulatory point of view, is to develop a guidance of best practices that could act as a basis for global harmonization and discussions regarding the SSD methodology and tools. Integr Environ Assess Manag 2017;13:664-674. (c) 2016 SETAC