Correlation between hemifield visual field damage and corresponding parapapillary atrophy in normal-tension glaucoma
Correlation between hemifield visual field damage and corresponding parapapillary atrophy in normal-tension glaucoma
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DOI：
10.1016/j.ajo.2006.01.087
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发表时间：
2006-07-01
影响因子：
4.2
通讯作者：
Araie, Makoto
中科院分区：
文献类型：
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作者：
Kawano, Junko;Tomidokoro, Atsuo;Araie, Makoto
目得：目的：探讨正常眼压性青光眼（normal-tensionalglaucoma，GAG）视乳头旁萎缩（parapillaratrophy，PPA）上级、下半区与相应半视野视野损害（hemifieldvisualfieldddame，VFD）的相关性。观察程序：用Heidelberg视网膜断层扫描仪（HRT）测量视乳头和PPA（P区）的地形图参数，用Humphrey视野分析仪的30：2程序评价VFD。分别测定上级和下半区的HRT参数和PPA面积。主要观察指标：PPA的上级和下级面积与屈光不正、眼轴长度、HRT参数和相应的半视野VFD的偏相关系数。结果：在简单相关分析中，PPA的下级面积与上级半视野VFD之间存在显著相关性（斯皮尔曼等级相关系数; Rs = -0.32; P <0.001），但上级PPA区域和下半野VFD之间无相关性（Rs = 0.05; P = 0.6）。年龄、屈光不正、眼轴长度和高度变化轮廓分别与PPA的总面积、上级面积和下级面积显著相关（P <0.01）。多元回归分析显示，上级PPA面积仅与眼轴长度显著相关（P <0.001），而下PPA面积与眼轴长度和上级半视野VFD显著相关（P <0.001）。眼轴长度和近视与PPA的上级和下半区相关。
PURPOSE: To evaluate the correlation between the superior or inferior half area of parapapillary atrophy (PPA) and the corresponding hemifield visual field dame age (VFD) in normal-tension glaucoma.DESIGN: Cross sectional study.METHODS: PATIENTS: One hundred nine eyes of 109 consecutive patients with normal-tension glaucoma. OBSERVATION PROCEDURES: Topography parameters of the optic nerve head and PPA (zone P) area were obtained with the Heidelberg Retina Tomograph (HRT), and VFD was evaluated with the 30 to 2 program of Humphrey Field Analyzer. The HRT parameters and PPA area were determined separately in superior and inferior half regions. MAIN OUTCOME MEASURES: Partial correlation coefficients of the superior and inferior areas of PPA with refractive error, axial length, HRT parameters, and corresponding hemifield VFD.RESULTS: In simple correlation analyses, significant correlation was found between the inferior PPA area and the superior hemifield VFD (Spearman rank correlation coefficient; Rs = -0.32; P < .001) but not between the superior PPA area and the inferior hemifield VFD (Rs = 0.05; P = .6). Age, refractive error, axial length, and height variation contour were associated significantly with the total, superior, and inferior areas of PPA, respectively (P < .01). Multiple regression analyses showed that the superior PPA area was associated significantly with only axial length (P < .001), and the inferior PPA area was associated significantly with the axial length and the superior hemifield VFD (P < .001).CONCLUSIONS: In patients with normal,tension glaucoma, only the inferior half area of PPA correlated significantly with glaucomatous VFD. Axial length and myopia were associated with both the superior and inferior half areas of PPA.