Essential fatty acid deficiency in human adults during total parenteral nutrition.
Essential fatty acid deficiency in human adults during total parenteral nutrition.
复制标题
全肠外营养期间成人必需脂肪酸缺乏。
DOI：
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发表时间：
1975
影响因子：
39.2
通讯作者：
B. Scribner
中科院分区：
文献类型：
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作者：
M. Riella;J. Broviac;M. Wells;B. Scribner
3例在家中接受长期全肠外营养的患者出现皮肤病变，其特征是干燥和鳞状外观，最初局限于皱褶，但随后普遍化。这些患者血浆中的脂肪酸测量显示明显异常的脂质模式：5,8,11-二十碳三烯酸（20:3 ω - 9）的积累和20:3 ω - 9与20:4 ω - 6的高比率。当给予500毫升/天的肠外脂肪（脂肪内）时，脂肪酸的连续测量显示异常模式逐渐正常化，皮肤病变显著改善。似乎成人每日对亚油酸的需取量，特别是在快速合成代谢期间，尚未明确确定。由于越来越多的患者变得部分或完全依赖肠外营养长时间，肠外脂肪制剂的可用性是迫切需要的。
Three patients undergoing prolonged total parenteral nutrition at home developed skin lesions, characterized by dryness and scaly appearance, initially confined to the folds but becoming subsequently generalized. Fatty acid measurements in plasma of these patients showed a markedly abnormal lipid pattern: accumulation of 5,8,11-eicosatrienoic acid (20:3omega9) and a high 20:3omega9-to-20:4omega6 ratio. When parenteral fat (Intralipid) was administered, 500 ml/day, serial measurements of fatty acids showed a progressive normalization of the abnormal pattern and a dramatic improvement in the skin lesions. It appears that the daily requirement for linoleic acid in the adult, particularly during the period of rapid anabolism, has not been clearly established. Because more and more patients are becoming partly or totally dependent on parenteral nutrition for prolonged periods of time, the availability of parenteral fat preparations is urgently needed.