Comparison of functional recovery of manual dexterity after unilateral spinal cord lesion or motor cortex lesion in adult macaque monkeys
Comparison of functional recovery of manual dexterity after unilateral spinal cord lesion or motor cortex lesion in adult macaque monkeys
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DOI：
10.3389/fneur.2013.00101
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发表时间：
2013-01-01
影响因子：
3.4
通讯作者：
Rouiller, Eric M.
中科院分区：
文献类型：
--
作者：
Hoogewoud, Florence;Hamadjida, Adjia;Rouiller, Eric M.
关于颈髓损伤或运动皮质损伤后手灵巧功能恢复的机制，我们的目标是确定损伤后功能恢复的运动特征是否与原始运动模式相当，或者猴子是否根据损伤类型采取不同的策略来补偿缺陷？为了达到这个目的，从早期的研究中获得的数据，使用熟练的手指任务（改进的Brinkman板，从垂直或水平槽中取出颗粒），在脊髓和运动皮层受伤的猴子中进行了分析和比较。12只成年猕猴接受了半颈髓切除术（n = 6）或原发性运动皮质单侧手部表现的兴奋性毒性病变（n = 6）。此外，在每个亚组中，一半的猴子（n = 3）接受针对神经突生长抑制蛋白Nogo-A的功能阻断抗体治疗30天，而另一半（n = 3）代表对照动物。评估运动缺陷、功能恢复的程度和时间进程。对于所研究的一些参数（颈椎损伤后腕关节水平槽的角度和垂直槽的运动类型分布；运动皮质损伤后水平槽的运动类型分布），损伤后原始运动模式的恢复（“真实”恢复）在定量上导致更好的功能恢复。在运动皮质损伤组中，药物可逆失活实验表明，初级运动皮质的笔状损伤区域或重新排列的损伤区，以及完整的运动前皮质在功能恢复中起主要作用。
In relation to mechanisms involved in functional recovery of manual dexterity from cervical cord injury or from motor cortical injury, our goal was to determine whether the movements that characterize post-lesion functional recovery are comparable to original movement patterns or do monkeys adopt distinct strategies to compensate the deficits depending on the type of lesion? To this aim, data derived from earlier studies, using a skilled finger task (the modified Brinkman board from which pellets are retrieved from vertical or horizontal slots), in spinal cord and motor cortex injured monkeys were analyzed and compared. Twelve adult macaque monkeys were subjected to a hemi-section of the cervical cord (n = 6) or to a unilateral excitotoxic lesion of the hand representation in the primary motor cortex (n = 6). In addition, in each subgroup, one half of monkeys (n = 3) were treated for 30 days with a function blocking antibody against the neurite growth inhibitory protein Nogo-A, while the other half (n = 3) represented control animals. The motor deficits, and the extent and time course of functional recovery were assessed. For some of the parameters investigated (wrist angle for horizontal slots and movement types distribution for vertical slots after cervical injury; movement types distribution for horizontal slots after motor cortex lesion), post-lesion restoration of the original movement patterns ("true" recovery) led to a quantitatively better functional recovery. In the motor cortex lesion groups, pharmacological reversible inactivation experiments showed that the pen-lesion territory of the primary motor cortex or re-arranged, spared domain of the lesion zone, played a major role in the functional recovery, together with the ipsilesional intact premotor cortex.