Nanochitosan enriched poly ε-caprolactone electrospun wound dressing membranes: A fine tuning of physicochemical properties, hemocompatibility and curcumin release profile.
Nanochitosan enriched poly ε-caprolactone electrospun wound dressing membranes: A fine tuning of physicochemical properties, hemocompatibility and curcumin release profile.
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DOI：
10.1016/j.ijbiomac.2017.11.035
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发表时间：
2017-11
影响因子：
8.2
通讯作者：
Reshmi Cr;S. Ps;Manaf O;Sanu Pp;Sujith A
中科院分区：
文献类型：
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作者：
Reshmi Cr;S. Ps;Manaf O;Sanu Pp;Sujith A
制备了纳米壳聚糖（NC）富集聚ε-己内酯（PCL）纳米纤维膜，用于姜黄素控释和伤口敷料。通过将NC掺入PCL中，观察到PCL的亲水性、PBS吸附性和水蒸气透射性显著增加。PCL/NC膜的溶血实验、血凝块动力学和血小板粘附研究证实了支架的血液相容性。NC还赋予适当的抗菌活性和生物相容性，有望成为伤口敷料。15% NC （PCL/15NC）负载膜在pH为7.4、5.8和1.2时表现出良好的生物利用度和姜黄素缓释行为，具有pH敏感性。因此，PCL/15NC纳米纤维膜在pH刺激下具有可调节的药物释放特性，是一种很有前景的伤口敷料和透皮贴材料。
Nanochitosan (NC) enriched Poly (ε-caprolactone) (PCL) nanofibrous membranes were fabricated for controlled curcumin delivery and wound dressing. A significant increase in hydrophilicity, PBS sorption, and vapour transmission were observed by incorporation of NC in PCL. Hemolysis assay, blood clot kinetics and platelet adhesion studies on PCL/NC membranes confirmed the hemocompatibility of the scaffold. NC also imparts appropriate antibacterial activity and biocompatibility promising for a wound dressing material. 15% NC (PCL/15NC) loaded membrane exhibits excellent bioavailability and sustained release behaviour of curcumin at different pH of 7.4, 5.8 and 1.2 with pH sensitive nature. Thus, it can be concluded that PCL/15NC nanofibrous membrane is a promising material for wound dressings and transdermal patches with tunable drug releasing properties with pH stimulus.