Relationship of bovine leukocyte adhesion deficiency with genetic merit for performance traits.
Relationship of bovine leukocyte adhesion deficiency with genetic merit for performance traits.
复制标题
牛白细胞粘附缺陷与性能性状遗传优点的关系。
作者：
R. L. Powell;H. Norman;C. Cowan
牛白细胞粘附缺陷症与其他性状的多效性或连锁的存在，以及去除隐性、不需要的等位基因对这些性状的遗传进展的影响的检查是有限的。在6400荷斯坦公牛测试的频率为8.2%，然而，报告是不完整的，因此，估计的载波频率是向下倾斜。对于AI采样的公牛，1989年采样的公牛的携带者频率达到23%的高点，但由于DNA测试和扑杀，此后下降到0%。关联的等位基因与产量，生产生活，体细胞评分进行了检查与模型中的女儿产量偏差减去父母的评价的平均值被解释为携带者状态。当忽略公畜的影响时，蛋白质产量与蛋白质产量呈显着负相关;所有关联都是不利的。连锁进行了检查，通过应用模型为四个父系家庭，只有蛋白质产量为一个父系显着和负相关的隐性等位基因。携带者公牛目前被贴上了标签，有些公牛因为其他性状的优越性而继续在人工智能中被积极使用。因此等位基因的多效性或基因座与所研究的性状的连锁是不可能的。这些性能性状的遗传进展不会因未能对携带者公牛取样而受到阻碍。
Examination of the existence of pleiotropy or linkage of bovine leukocyte adhesion deficiency with other traits and of the impact of removal of the recessive, undesirable allele on genetic progress for those traits has been limited. Frequency of carriers among 6400 Holstein bulls tested was 8.2%; however, reporting was incomplete, and, therefore, the estimate of carrier frequency was biased downward. For AI-sampled bulls, carrier frequency reached a high of 23% for bulls sampled during 1989 but declined to 0% since then because of DNA testing and culling. Association of the allele with yield, productive life, and somatic cell score was examined with a model in which the daughter yield deviation minus the mean of parent evaluations was explained by carrier status. A significant negative relationship was found with protein yield when effect of sires was ignored; all associations were unfavorable. Linkage was examined by applying the model for each of four sire families; only protein yield for one sire was significantly and negatively related to the recessive allele. Carrier bulls currently are labeled, and some continue to be used actively in AI because of superiority for other traits. Consequential pleiotropy of the allele or linkage of the locus with the traits studied is unlikely. Genetic progress for these performance traits will not be impeded by failure to sample carrier bulls.
牛白细胞粘附缺陷的临床表现：14例（1977-1991）。
DOI：
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发表时间：
1993
期刊：
Journal of the American Veterinary Medical Association
影响因子：
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作者：
Gilbert,RO;Rebhun,WC;Kim,CA;KehrliJr,ME;Shuster,DE;Ackermann,MR
通讯作者：
Ackermann,MR