Clinical Characteristics and Outcomes of Patients with Cardiac Defects and Congenital Diaphragmatic Hernia
Clinical Characteristics and Outcomes of Patients with Cardiac Defects and Congenital Diaphragmatic Hernia
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DOI：
10.1016/j.jpeds.2012.06.048
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发表时间：
2013-01-01
影响因子：
5.1
通讯作者：
Yoder, Bradley A.
中科院分区：
文献类型：
--
作者：
Menon, Shaji C.;Tani, Lloyd Y.;Yoder, Bradley A.
目的评估相关心脏缺陷对出院结局的影响，并确定影响所有先天性膈疝（CDH）婴儿生存的因素，在过去的十年中使用先天性膈疝研究组data.Study设计这是一个回顾性的审查，所有先天性膈疝研究组数据库中登记的婴儿CDH从2000年1月至2010年12月。研究队列分为3组（GRP）：GRP 1，CDH伴严重心脏缺陷; GRP 2，CDH伴轻度心脏缺陷; GRP 3，CDH无心脏缺陷。结果4268例入组婴儿包括GRP 1组345例（8%），GRP 2组412例（10%），GRP 3组3511例（82%）。与GRP 2和GRP 3相比，GRP 1的生存率显著较低（36% vs 73%）。在GRP 1中，最常见的缺陷是左心梗阻性病变（34%）。大动脉转位（0%）和单心室生理（16%）婴儿的存活率最低。2000-2005年和2006-2010年期间，任何群体的存活率都没有变化。在GRP 1中，预测的因素。存活率较低的是出生体重
Objective To evaluate the impact of associated heart defects on outcomes to discharge, and identify factors affecting survival of all infants born with congenital diaphragmatic hernia (CDH) in last decade using Congenital Diaphragmatic Hernia Study Group data.Study design This was a retrospective review of all infants with CDH enrolled in Congenital Diaphragmatic Hernia Study Group database from January 2000 to December 2010. The study cohort was divided into 3 groups (GRP): GRP 1, CDH with major heart defects; GRP 2, CDH with minor heart defects; and GRP 3, CDH with no reported heart defects.Results The 4268 enrolled infants included 345(8%) in GRP 1,412 (10%) in GRP 2, and 3511 (82%) in GRP 3. Survival was significantly lower in GRP 1 compared with GRP 2 and GRP 3 (36% vs 73%). In GRP 1, the most common defects were left heart obstructive lesions (34%). Survival was lowest in infants with transposition of great arteries (0%) and single ventricle physiology (16%). There was no change in survival rate for any group between 2000-2005 and 2006-2010. In GRP 1, factors that predicted. lower survival were birth weight