COMPARATIVE SITE OF ACTION OF VARIOUS ANESTHETIC AGENTS AT MAMMALIAN MYONEURAL JUNCTION
COMPARATIVE SITE OF ACTION OF VARIOUS ANESTHETIC AGENTS AT MAMMALIAN MYONEURAL JUNCTION
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DOI：
10.1093/bja/47.5.533
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发表时间：
1975-01-01
影响因子：
9.8
通讯作者：
GALINDO, AD
中科院分区：
文献类型：
--
作者：
KENNEDY, RD;GALINDO, AD
摘要采用标准微电极记录技术研究了三种醚类（安氟醚、乙醚和甲氧氟醚）和三种非醚类（氯仿、氟烷和三氯乙烯）在大鼠膈神经膈肌制备中的连接前和连接后效应。抑制连接后功能包括抑制微型终板电位的幅度，抑制琥珀胆碱诱导的肌肉终板去极化，延长终板电位的持续时间，增加产生肌肉动作电位的阈值。最后两个效果是更显着的醚比非醚。对交界前功能的影响包括与乙醚和氯仿相关的终板电位（EPP）振幅波动略有增加，在乙醚存在的情况下破伤风期间EPP振幅下降速度更快，以及延长正常易化期在成对刺激期间氯仿的存在。氯仿对强直刺激时EPP振幅的下降率没有影响，乙醚对成对刺激时的易化期没有影响。这些结果表明，挥发性麻醉剂通过作用于多个部位来抑制突触传递，并且这种抑制的模式对于每种药物或类似药物的组是不同的。
SUMMARYPre- and postjunctional effects of three ethers (enflurane, diethyl ether, and methoxyflurane) and three non-ethers (chloroform, halothane, and trichloroethylene) were studied in the rat phrenic nerve diaphragm preparation using standard microelectrode recording techniques. Depression of postjunctional function included depression of the amplitude of miniature endplate potentials, inhibition of suxamethonium induced depolarization of the muscle endplate, prolongation of duration of the endplate potential, and increase in threshold for generation of the muscle action potential. The last two effects were more marked for the ethers than for the non-ethers. Effects on prejunctional function included a slight increase in fluctuation of the endplate potential (EPP) amplitude associated with the ethers and chloroform, a faster rate of decline of EPP amplitude during a tetanus in presence of the ethers, and prolongation of the normal facilitatory period during paired stimulation in the presence of chloroform. Chloroform had no effect on the rate of decline of EPP amplitude during tetanic stimulation and the ethers had no effect on the facilitatory period during paired stimulation. These results indicate that volatile anaesthetic agents depress synaptic transmission by acting on multiple sites, and that the pattern of this depression is different for each drug or group of similar drugs.