PIF4 Coordinates Thermosensory Growth and Immunity in Arabidopsis.
PIF4 Coordinates Thermosensory Growth and Immunity in Arabidopsis.
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PIF4协调拟南芥中的热增长和免疫力。
DOI：
10.1016/j.cub.2016.11.012
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发表时间：
2017-01-23
期刊：
影响因子：
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通讯作者：
Kumar SV
中科院分区：
文献类型：
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作者：
Gangappa SN;Berriri S;Kumar SV
温度是影响植物生长的关键季节信号。升高的环境温度加速生长和发育转变，同时损害植物防御，导致易感性增加。在升高的温度下免疫力的抑制处于生长和防御之间的权衡界面。气候变化和生长季节平均温度的上升威胁着生物多样性和粮食安全。尽管它的重要性，连接热敏生长和防御反应的分子机制尚不清楚。在这里，我们表明，植物色素相互作用因子4（PIF 4）介导的热敏生长和结构适应直接关系到在高温下的免疫抑制。PIF 4正调节生长和发育，负调节免疫力。我们还表明，PIF 4介导的温度反应的自然变化是拟南芥天然菌株之间生长和防御平衡变化的基础。重要的是，我们发现PIF 4功能的调节改变了防御的温度敏感性。PIF 4介导的生长的扰动导致了温度适应性抗病性。这项研究揭示了植物热敏生长和免疫之间的分子联系。阐明定义环境信号整合的分子机制是开发作物温度适应性抗病育种新策略的关键。转录因子PIF 4协调热敏生长和免疫PIF 4负调节免疫，同时促进生长PIF 4信号的自然变化是野生型生长-防御平衡的基础PIF 4信号的调节改变抗病性的温度敏感性Gangappa et al.显示转录因子PIF 4协调热敏生长和免疫。PIF 4作为植物免疫的负调节剂，其功能的调节改变了生长和防御之间的平衡。重要的是，PIF 4信号的自然变异是拟南芥天然菌株生长-防御平衡的基础。
Temperature is a key seasonal signal that shapes plant growth. Elevated ambient temperature accelerates growth and developmental transitions while compromising plant defenses, leading to increased susceptibility. Suppression of immunity at elevated temperature is at the interface of trade-off between growth and defense. Climate change and the increase in average growth-season temperatures threaten biodiversity and food security. Despite its significance, the molecular mechanisms that link thermosensory growth and defense responses are not known. Here we show that PHYTOCHROME INTERACTING FACTOR 4 (PIF4)-mediated thermosensory growth and architecture adaptations are directly linked to suppression of immunity at elevated temperature. PIF4 positively regulates growth and development and negatively regulates immunity. We also show that natural variation of PIF4-mediated temperature response underlies variation in the balance between growth and defense among Arabidopsis natural strains. Importantly, we find that modulation of PIF4 function alters temperature sensitivity of defense. Perturbation of PIF4-mediated growth has resulted in temperature-resilient disease resistance. This study reveals a molecular link between thermosensory growth and immunity in plants. Elucidation of the molecular mechanisms that define environmental signal integration is key to the development of novel strategies for breeding temperature-resilient disease resistance in crops. Transcription factor PIF4 coordinates thermosensory growth and immunity PIF4 negatively regulates immunity, while promoting growth Natural variation of PIF4 signaling underlies growth-defense balance in the wild Modulation of PIF4 signaling alters temperature sensitivity of disease resistance Gangappa et al. show that the transcription factor PIF4 coordinates thermosensory growth and immunity. PIF4 acts as a negative regulator of plant immunity, and modulation of its function alters the balance between growth and defense. Importantly, natural variation of PIF4 signaling underlies growth-defense balance in Arabidopsis natural strains.