Effects of Crocus sativus L. on the ethanol-induced impairment of passive avoidance performances in mice.
Effects of Crocus sativus L. on the ethanol-induced impairment of passive avoidance performances in mice.
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番红花对乙醇引起的小鼠被动回避表现损伤的影响。
DOI：
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发表时间：
1994
影响因子：
2
通讯作者：
H. Saito
中科院分区：
文献类型：
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作者：
Yongxiang Zhang;Y. Shoyama;M. Sugiura;H. Saito
番红花乙醇提取物的急性毒性作用。（CS-提取物）在正常小鼠以及学习和记忆受损的小鼠中在逐步通过（ST）和逐步下降（SD）测试中的学习和记忆方面进行了研究。单次口服CS提取物对正常小鼠的记忆登记、巩固或提取没有影响。CS-提取物可减轻乙醇引起的ST和SD试验中记忆记录的损害，以及乙醇引起的SD试验中记忆提取的损害。CS-Extract可降低运动活动（MA），延长己巴比妥诱导的睡眠时间。这些结果表明，CS提取物改善乙醇对学习记忆过程的损害作用，并具有镇静作用。
The acute effects of an alcohol extract of Crocus sativus L. (CS-extract) were studied on learning and memory in step through (ST) and step down (SD) tests in normal as well as in learning- and memory-impaired mice. A single oral administration of CS-extract had no effects on memory registration, consolidation or retrieval in normal mice. CS-Extract reduced the ethanol-induced impairment of memory registration both in ST and SD tests and the ethanol-induced impairment of memory retrieval in SD test. CS-Extract decreased the motor activity (MA) and prolonged the sleeping time induced by hexobarbital. These results suggested that CS-extract ameliorates the impairment effects of ethanol on learning and memory processes, and possesses a sedative effect.