GATA factor switching during erythroid differentiation
GATA factor switching during erythroid differentiation
复制标题
红细胞分化过程中的 GATA 因子转换
DOI：
10.1097/moh.0b013e32833800b8
复制
发表时间：
2010-05-01
影响因子：
3.2
通讯作者：
Yamamoto, Masayuki
中科院分区：
文献类型：
--
作者：
Kaneko, Hiroshi;Shimizu, Ritsuko;Yamamoto, Masayuki
综述目的
人们已经努力去了解红细胞分化是如何被调控的，并且近期的发现阐明了谱系特异性转录因子网络对于红细胞的正常分化至关重要。转录因子GATA1和GATA2参与了调控红细胞基因表达的此类网络。重要的是，Gata1和Gata2基因的表达也受此类调控网络的控制。本综述聚焦于红细胞生成过程中Gata1和Gata2基因调控的机制以及它们动态调控的生理意义。
近期发现
Gata1和Gata2基因受到多种转录因子的调控，包括它们自身的产物GATA1和GATA2。GATA1和GATA2识别特定的调控性GATA基序，并且它们的表达水平在红细胞分化过程中动态变化，导致红细胞生成过程中基因表达的多样化。
总结
对Gata1和Gata2基因的严格调控对于红细胞的正确谱系定型和发育至关重要。在转基因小鼠分析中已经表明，顺式作用的GATA结合基序对于Gata1和Gata2基因的表达至关重要。此外，Gata1和Gata2基因以及一组红细胞基因的表达似乎是由GATA因子转换来调控的。
Purpose of reviewEfforts have been made to understand how erythroid differentiation is regulated, and recent discoveries have clarified that lineage-specific transcription factor networks are essential for proper differentiation of erythroid cells. The transcription factors GATA1 and GATA2 are involved in such networks that regulate erythroid gene expression. Importantly, expression of Gata1 and Gata2 genes is also under the control of such regulatory networks. The present review is focused on the mechanism of Gata1 and Gata2 gene regulation during erythropoiesis and the physiological significance of their dynamic regulation.Recent findingsGata1 and Gata2 genes are regulated by multiple transcription factors, including their own products GATA1 and GATA2. GATA1 and GATA2 recognize specific regulatory GATA motifs, and their expression levels change dynamically during erythroid differentiation, leading to diversified gene expression during erythropoiesis.SummaryStrict regulations of the Gata1 and Gata2 genes are critical for proper lineage commitment and development of erythroid cells. It has been shown in transgenic mouse analyses that cis-acting GATA binding motifs are critical for the expression of Gata1 and Gata2 genes. Furthermore, expression of Gata1 and Gata2 genes along with a set of erythroid genes appeared to be regulated by GATA factor switching.