Dopaminergic neuron B20 generates rhythmic neuronal activity in the feeding motor circuitry ofAplysia
Dopaminergic neuron B20 generates rhythmic neuronal activity in the feeding motor circuitry ofAplysia
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DOI：
10.1016/0006-8993(93)90661-6
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发表时间：
1993-12
期刊：
影响因子：
2.9
通讯作者：
T. Teyke;S. Rosen;K. R. Weiss;I. Kupfermann
中科院分区：
文献类型：
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作者：
T. Teyke;S. Rosen;K. R. Weiss;I. Kupfermann
我们已经确定了一个颊神经元（B20），表现出多巴胺样组织荧光，并可以驱动一个有节奏的运动程序的摄食运动电路ofAfricsia。在自发发生的模式化口腔活动期间，或在由刺激识别的大脑命令样神经元以进行进食运动程序而引起的口腔程序期间，细胞强烈地发射。阻止B20放电，或在不适当的时间放电B20，可以修改由大脑进食命令样神经元CBI-2驱动的程序。当B20通过恒定的去极化电流激活时，它以阶段性爆发放电，并唤起持续协调的节律性颊运动程序。这个程序结合了许多与进食反应有关的颊和大脑神经元。B20驱动的程序可以可逆地阻断多巴胺拮抗剂麦角新碱，表明多巴胺可能是因果关系参与的程序的产生。虽然B20的放电引起大脑命令样神经元的阶段性活动，但脑神经节的存在并不是B20驱动程序所必需的。这些数据与多巴胺能神经元B20是与进食相关的运动程序的中央模式发生器内的元素的概念一致。
We have identified a buccal neuron (B20) that exhibits dopamine-like histofluorescence and that can drive a rhythmic motor program of the feeding motor circuitry ofAplysia. The cell fires vigorously during episodes of patterned buccal activity that occur spontaneously, or during buccal programs elicited by stimulation of identified cerebral command-like neurons for feeding motor programs. Preventing B20 from firing, or firing B20 at inappropriate times, can modify the program driven by the cerebral feeding command-like neuron CBI-2. When B20 is activated by means of constant depolarizing current it discharges in phasic bursts, and evokes a sustained coordinated rhythmic buccal motor program. This program incorporates numerous buccal and cerebral neurons associated with aspects of feeding responses. The B20-driven program can be reversibly blocked by the dopamine-antagonist ergonovine, suggesting that dopamine may be causally involved in the generation of the program. Although firing of B20 evokes phasic activity in cerebral command-like neurons, the presence of the cerebral ganglion is not necessary for B20 to drive the program. The data are consistent with the notion that dopaminergic neuron B20 is an element within the central pattern generator for motor programs associated with feeding.