Rhythmicities in sympathetic discharge: a signal of cardiorespiratory integration in developing animals.
Rhythmicities in sympathetic discharge: a signal of cardiorespiratory integration in developing animals.
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交感神经放电的节律：发育中动物心肺整合的信号。
DOI：
10.1111/j.1749-6632.2001.tb03695.x
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发表时间：
2001
影响因子：
5.2
通讯作者：
Gootman,PM
中科院分区：
文献类型：
--
作者：
Hundley,BW;Sica,AL;Gootman,PM
摘要：我们一直在寻求各种途径的研究，以阐明出生后成熟的神经调节心血管和呼吸整合。在这篇论文中，我们系统分析了年龄相关的交感神经（SYMP）活动调节与压力感受器传入输入实验改变的关系。根据对复杂刺激（即Valsalva动作）的不同反应来选择三个年龄组的仔猪。通过交叉功率、全相干和部分相干的SYMP放电光谱分析来检测出生后SYMP活动的成熟。在0-30 Hz范围内，在自发的SYMP放电中观察到三种一般振荡。我们将该范围分为5个频段（0 - 2,2 - 6,6 - 12,12 - 20,20 - 30hz），其中包括与中枢呼吸活动和心脏周期相一致的周期性。对压力感受器激活（苯肾上腺素）或失活（硝普塞）后的SYMP活性的频谱分析显示，呼吸调节在所有频率上都与年龄相关，而压力感受器调节通常在五个频段中的三个频段上与年龄相关。这些结果引发了关于自主神经系统和/或呼吸和SYMP节律产生者之间的中枢相互作用在婴儿猝死综合征（SIDS）病因学中的可能作用的问题。
Abstract:We have been pursuing various avenues of investigation to elucidate the postnatal maturation of neural regulation of cardiovascular and respiratory integration. In this paper we present our results from a systematic analysis of age‐related modulations of sympathetic (SYMP) activity with respect to experimental alterations in baroreceptor afferent inputs. The three age groups of piglets were chosen based on different responses to a complex stimulus, i.e., the Valsalva maneuver. Postnatal maturation of SYMP activity was examined by spectral analysis of SYMP discharge using cross‐power, full and partial coherence. Three general oscillations were observed in spontaneous SYMP discharges in the 0–30 Hz range. We divided that range into five frequency bands (0–2, 2–6, 6–12, 12–20, 20–30 Hz), which included periodicities in phase with both central respiratory activity and the cardiac cycle. Spectral analyses of SYMP activity after either baroreceptor activation (phenylephrine) or deactivation (nitroprusside) revealed that respiratory modulation was age‐related across all frequencies while baroreceptor modulation was usually age‐related within three of the five frequency bands. These results lead to questions concerning the possible role of the autonomic nervous system and/or central interactions between the respiratory and SYMP rhythm generators in the etiology of sudden infant death syndrome (SIDS).