Idiopathic retroperitoneal fibrosis associated with immunohematological abnormalities
Idiopathic retroperitoneal fibrosis associated with immunohematological abnormalities
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DOI：
10.1016/j.amjmed.2005.02.004
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发表时间：
2005-07-01
影响因子：
5.9
通讯作者：
Kudo, M
中科院分区：
文献类型：
--
作者：
Oshiro, H;Ebihara, Y;Kudo, M
特发性腹膜后纤维化以致密纤维结缔组织沉积和不同程度的淋巴样细胞浸润为特征。(1)对本病的一些描述还涉及浆细胞畸变、淋巴样细胞核不规则和克隆基因重排。（2,3）在最初诊断为特发性腹膜后纤维化及相关疾病后，恶性淋巴瘤的发病率报告（4-8）表明，这些硬化实体可能应归类为淋巴样病变，这可能容易形成低级别恶性淋巴瘤。(3)本研究旨在进一步探讨特发性腹膜后纤维化病例的免疫血液学异常。
Idiopathic retroperitoneal fibrosis is characterized by the deposition of dense fibrous connective tissue and varying degrees of lymphoid cell infiltration.(1) Some descriptions of this disease also refer to the presence of distorted plasma cells and to nuclear irregularities and clonal gene rearrangement in the lymphoid cells.(2,3) Reports of the incidence of malignant lymphoma, following an initial diagnosis of idiopathic retroperitoneal fibrosis and associated condition,(4-8) suggest that these sclerosing entities should perhaps be classified as lymphoid dyscrasia, which may be predisposed to forming low grade malignant lymphomas.(3) The aim of this study was to further investigate immunohematological abnormalities in cases of idiopathic retroperitoneal fibrosis.