A method for estimating contact time of red blood cells through lung capillary from O2 and CO2 concentrations in rebreathing air in man.
A method for estimating contact time of red blood cells through lung capillary from O2 and CO2 concentrations in rebreathing air in man.
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一种根据人体再呼吸空气中的 O2 和 CO2 浓度估算红细胞通过肺毛细血管的接触时间的方法。
DOI：
10.2170/jjphysiol.37.283
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
T. Kagawa
中科院分区：
文献类型：
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作者：
M. Mochizuki;I. Shibuya;K. Uchida;T. Kagawa
从再呼吸空气中测量的O2和CO2浓度获得的气体交换率（R）通常与PCO 2呈线性关系。通过参考该关系式和等于Halcantine效应系数和零的R，除了肺泡PCO 2之外，还获得了真实和充氧静脉PCO 2。当评估这些PCO 2时，R-PCO 2线也可以从红细胞中总体O2和CO2扩散的数值解理论上计算。通过比较实验和理论的R-PCO 2线，我们推导出了接触时间方程。由于R-PCO 2关系的线性近似引起接触时间（tc）的误差，因此首先导出校正R-PCO 2线的线性的因子。接着，使用这些参数值，从5名正常受试者在再呼吸期间获得的实验数据中定量地确定tc，并将其与在相同的再呼吸实验中从CO的肺弥散量估计的tc进行比较。当细胞外HCO_3-脱水速率为0.1s时，tc_i约为0.1s。0.7和0.4 s，分别在休息和运动期间，表现出良好的协议，从CO的扩散能力。
The gas exchange ratio (R) obtained from O2 and CO2 concentrations measured in rebreathing air usually shows a linear relation to the PCO2. By referring to this relation and the R which equals the Haldane effect coefficient and zero, the true- and oxygenated-venous PCO2 are obtained in addition to the alveolar PCO2. When these PCO2 are evaluated, the R-PCO2 line can also be computed theoretically from a numerical solution on the overall O2 and CO2 diffusions in the red blood cell. By comparing both the experimental and theoretical R-PCO2 lines with each other, we derived a contact time equation. Since the linear approximation of the R-PCO2 relation gave rise to an error in the contact time (tc), first a factor to correct the linearity of the R-PCO2 line was derived. Next, using these parameter values, tc was quantitatively determined from experimental data obtained during rebreathing in 5 normal subjects and it was compared with that estimated from the pulmonary diffusing capacity for CO in the same rebreathing experiment. When the extracellular HCO3- dehydration rate was taken to be 0.1 s in time constant, the tc, being ca. 0.7 and 0.4 s at rest and during exercise, respectively, showed good agreement with those obtained from the diffusing capacity for CO.
DOI：
10.1152/jappl.1983.55.1.75
发表时间：
1983
期刊：
Journal of applied physiology: respiratory, environmental and exercise physiology
影响因子：
--
作者：
Bidani,A;Mathew,SJ;Crandall,ED
通讯作者：
Crandall,ED