Interleukin‐10 does not modulate clopidogrel platelet response in mice
Interleukin‐10 does not modulate clopidogrel platelet response in mice
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DOI：
10.1111/jth.13238
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发表时间：
2016-02
影响因子：
10.4
通讯作者：
Q. Yin;T. Tai;Jialing Ji;Qiong-Yu Mi;M-R Zhang;Wenjuan Huang;Cheng-Chun Cao;H. Xie
中科院分区：
文献类型：
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作者：
Q. Yin;T. Tai;Jialing Ji;Qiong-Yu Mi;M-R Zhang;Wenjuan Huang;Cheng-Chun Cao;H. Xie
目前尚不清楚白细胞介素- 10 （IL - 10）是否会影响氯吡格雷的代谢和反应。用IL - 10和非IL - 10测定小鼠对氯吡格雷的生物活性和反应。最大氯吡格雷活性代谢物水平是血小板对氯吡格雷反应的主要驱动因素。IL‐10不调节氯吡格雷活性代谢物的最大水平及其抗血小板作用。
Essentials It is unclear whether interleukin‐10 (IL‐10) could affect clopidogrel metabolism and response. The bioactivation of and response to clopidogrel were determined between mice with or without IL‐10. Maximum clopidogrel active metabolite levels were the major driver of platelet response to clopidogrel. IL‐10 did not modulate maximum levels of clopidogrel active metabolite and its antiplatelet effects.