Left Ventricular Hypertrophy Phenotype in Childhood-Onset Essential Hypertension.
Left Ventricular Hypertrophy Phenotype in Childhood-Onset Essential Hypertension.
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DOI：
10.1111/jch.12708
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发表时间：
2016-05
期刊：
影响因子：
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通讯作者：
McNiece-Redwine K
中科院分区：
文献类型：
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作者：
Gupta-Malhotra M;Hashmi SS;Poffenbarger T;McNiece-Redwine K
我们的目的是确定89名未经治疗的原发性高血压(HTN)儿童与左心室肥厚(LVH)相关的危险因素。24小时动态血压监测确诊为临床高血压。计算左心室重量指数为LVm(G)/身高(M)2.7，左心室肥厚定义为左心室重量指数第95百分位数。对32例有左室肥厚和57例无左室肥厚的儿童进行比较。肥胖和收缩压都与LVH独立相关，BMI对LVH的贡献更大。肥胖的影响很大，患左室肥厚的风险增加了近9倍。有证据表明肥胖的存在或不存在对收缩压和左心室肥厚之间的关系有影响，因此这种关系主要存在于非肥胖者而不是肥胖者。因此，要逆转左心室肥厚，临床医生应同时考虑血压控制和体重管理。
Our aim was to determine the risk factors associated with left ventricular hypertrophy (LVH) among 89 untreated children with primary hypertension (HTN). Clinic hypertension was confirmed by 24-hour ambulatory BP monitoring. Left ventricular mass index was calculated as LVM (g)/height (m) 2.7, and LVH was defined as LVMI >95th percentile. Children with (n = 32) and without LVH (n = 57) were compared. Both obesity and systolic BP were independently associated with LVH, with a higher contribution by the BMI. Obesity contributed significantly, with a nearly 9 fold increased risk of LVH. There was evidence of effect modification by the presence or absence of obesity on the relationship between systolic BP and LVH, whereby the relationship existed mainly in the non-obese rather than the obese children. Hence, to achieve reversal of LVH, clinicians should take into account both BP control and weight management.