A complement receptor locus: genes encoding C3b/C4b receptor and C3d/Epstein-Barr virus receptor map to 1q32.
A complement receptor locus: genes encoding C3b/C4b receptor and C3d/Epstein-Barr virus receptor map to 1q32.
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DOI：
10.4049/jimmunol.138.1.312
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发表时间：
1987-01
影响因子：
4.4
通讯作者：
J. Weis;C. Morton;G. Bruns;J. Weis;L. Klickstein;W. Wong;D. Fearon
中科院分区：
文献类型：
--
作者：
J. Weis;C. Morton;G. Bruns;J. Weis;L. Klickstein;W. Wong;D. Fearon
补体系统组分C3的替代或经典途径可由微生物和抗原-抗体复合物触发。特别地，C3的活化片段C3 b共价连接到微生物或抗原-抗体复合物，其进而结合到C3 b受体，也称为补体受体1。编码构成C3激活酶的蛋白质的基因已被克隆并映射到主要组织相容性复合体中的“补体激活”位点，我们在这项研究中证明了这样一个位点在1号染色体长臂上的带1 q32。
The alternative or classical pathways for complement system component C3 may be triggered by microorganisms and antigen-antibody complexes. In particular, an activated fragment of C3, C3b, covalently attaches to microorganisms or antigen-antibody complexes, which in turn bind to the C3b receptor, also known as complement receptor 1. The genes encoding the proteins that constitute the C3-activating enzymes have been cloned and mapped to a "complement activation" locus in the major histocompatibility complex, and we demonstrate in this study such a locus on the long arm of chromosome 1 at band 1q32.